Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines

A major critical issue in systemically administered nanomedicines is nonspecific clearance by the liver sinusoidal endothelium, causing a substantial decrease in the delivery efficiency of nanomedicines into the target tissues. Here, we addressed this issue by in situ stealth coating of liver sinuso...

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Detalles Bibliográficos
Autores principales: Dirisala, Anjaneyulu, Uchida, Satoshi, Toh, Kazuko, Li, Junjie, Osawa, Shigehito, Tockary, Theofilus A., Liu, Xueying, Abbasi, Saed, Hayashi, Kotaro, Mochida, Yuki, Fukushima, Shigeto, Kinoh, Hiroaki, Osada, Kensuke, Kataoka, Kazunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319729/
https://www.ncbi.nlm.nih.gov/pubmed/32637625
http://dx.doi.org/10.1126/sciadv.abb8133

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