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Doa10 is a membrane protein retrotranslocase in ER-associated protein degradation

In endoplasmic reticulum-associated protein degradation (ERAD), membrane proteins are ubiquitinated, extracted from the membrane, and degraded by the proteasome. The cytosolic ATPase Cdc48 drives extraction by pulling on polyubiquitinated substrates. How hydrophobic transmembrane (TM) segments are m...

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Detalles Bibliográficos
Autores principales:	Schmidt, Claudia C, Vasic, Vedran, Stein, Alexander
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319771/ https://www.ncbi.nlm.nih.gov/pubmed/32588820 http://dx.doi.org/10.7554/eLife.56945

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