High dose-rate brachytherapy of localized prostate cancer converts tumors from cold to hot

BACKGROUND: Prostate cancer (PCa) has a profoundly immunosuppressive microenvironment and is commonly immune excluded with few infiltrative lymphocytes and low levels of immune activation. High-dose radiation has been demonstrated to stimulate the immune system in various human solid tumors. We hypo...

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Detalles Bibliográficos
Autores principales: Keam, Simon P, Halse, Heloise, Nguyen, Thu, Wang, Minyu, Van Kooten Losio, Nicolas, Mitchell, Catherine, Caramia, Franco, Byrne, David J, Haupt, Sue, Ryland, Georgina, Darcy, Phillip K, Sandhu, Shahneen, Blombery, Piers, Haupt, Ygal, Williams, Scott G, Neeson, Paul J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319782/
https://www.ncbi.nlm.nih.gov/pubmed/32581061
http://dx.doi.org/10.1136/jitc-2020-000792

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