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Early Squamous Cell Carcinoma With Perineural Invasion: A Prospective Study Examining Anatomic Site, Tumor Surface Diameter, Invasion Depth, and Grade of Differentiation in 1,772 Consecutive Cases

BACKGROUND: Squamous cell carcinoma (SCC) may present with perineural invasion (PNI). OBJECTIVE: To investigate the characteristics of early invasive SCC with or without PNI. METHODS: Consecutive SCC excisions were prospectively reviewed from a single Australian community-based practice for 2016-201...

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Autores principales: Pyne, John H., Myint, Esther, Clark, Simon P., Gorji, Maddie, Hou, Ruihang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Dermoscopy Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319792/
https://www.ncbi.nlm.nih.gov/pubmed/32642309
http://dx.doi.org/10.5826/dpc.1003a59
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author Pyne, John H.
Myint, Esther
Clark, Simon P.
Gorji, Maddie
Hou, Ruihang
author_facet Pyne, John H.
Myint, Esther
Clark, Simon P.
Gorji, Maddie
Hou, Ruihang
author_sort Pyne, John H.
collection PubMed
description BACKGROUND: Squamous cell carcinoma (SCC) may present with perineural invasion (PNI). OBJECTIVE: To investigate the characteristics of early invasive SCC with or without PNI. METHODS: Consecutive SCC excisions were prospectively reviewed from a single Australian community-based practice for 2016-2018. Tumor characteristics recorded were anatomic site, maximum microscopic tumor surface diameter, invasion depth, grade of differentiation, and diameter of nerves with PNI. RESULTS: In total, 1,772 cases were collected. No PNI cases were found on female patients. Seven of the total 10 PNI cases were on facial sites. Maximum average microscopic tumor surface diameters ranged from 10.1 mm (well differentiated) up to 11.0 mm (moderately differentiated). Maximum average invasion depths by differentiation ranged from 1.7 (well differentiated) up to 2.6 mm (poorly differentiated). The PNI cases were as follows: well differentiated (n = 0), moderately differentiated (n = 4), or poorly differentiated (n = 6). Minimum average histopathological margins for well, moderately, and poorly differentiated SCC, respectively, were 1.4, 1.1, and 1.3 mm. Minimum microscopic tumor surface diameters for PNI cases were 7 mm for moderately and 5 mm for poorly differentiated SCC. Minimum microscopic invasion depths for PNI cases were 2.2 mm for moderate and 0.9 mm for poor differentiation. CONCLUSIONS: We found early SCC with PNI displayed nerve diameters of 0.1 mm or less and were exclusively on male patients aged 60 or older, on chronically sun-exposed sites of the head and upper midline anterior chest. Histopathological features associated with PNI were moderate and poor differentiation, tumor invasion beyond 0.9 mm, and adjacent lymphocytosis.
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spelling pubmed-73197922020-07-07 Early Squamous Cell Carcinoma With Perineural Invasion: A Prospective Study Examining Anatomic Site, Tumor Surface Diameter, Invasion Depth, and Grade of Differentiation in 1,772 Consecutive Cases Pyne, John H. Myint, Esther Clark, Simon P. Gorji, Maddie Hou, Ruihang Dermatol Pract Concept Research BACKGROUND: Squamous cell carcinoma (SCC) may present with perineural invasion (PNI). OBJECTIVE: To investigate the characteristics of early invasive SCC with or without PNI. METHODS: Consecutive SCC excisions were prospectively reviewed from a single Australian community-based practice for 2016-2018. Tumor characteristics recorded were anatomic site, maximum microscopic tumor surface diameter, invasion depth, grade of differentiation, and diameter of nerves with PNI. RESULTS: In total, 1,772 cases were collected. No PNI cases were found on female patients. Seven of the total 10 PNI cases were on facial sites. Maximum average microscopic tumor surface diameters ranged from 10.1 mm (well differentiated) up to 11.0 mm (moderately differentiated). Maximum average invasion depths by differentiation ranged from 1.7 (well differentiated) up to 2.6 mm (poorly differentiated). The PNI cases were as follows: well differentiated (n = 0), moderately differentiated (n = 4), or poorly differentiated (n = 6). Minimum average histopathological margins for well, moderately, and poorly differentiated SCC, respectively, were 1.4, 1.1, and 1.3 mm. Minimum microscopic tumor surface diameters for PNI cases were 7 mm for moderately and 5 mm for poorly differentiated SCC. Minimum microscopic invasion depths for PNI cases were 2.2 mm for moderate and 0.9 mm for poor differentiation. CONCLUSIONS: We found early SCC with PNI displayed nerve diameters of 0.1 mm or less and were exclusively on male patients aged 60 or older, on chronically sun-exposed sites of the head and upper midline anterior chest. Histopathological features associated with PNI were moderate and poor differentiation, tumor invasion beyond 0.9 mm, and adjacent lymphocytosis. International Dermoscopy Society 2020-06-29 /pmc/articles/PMC7319792/ /pubmed/32642309 http://dx.doi.org/10.5826/dpc.1003a59 Text en ©2020 Pyne et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research
Pyne, John H.
Myint, Esther
Clark, Simon P.
Gorji, Maddie
Hou, Ruihang
Early Squamous Cell Carcinoma With Perineural Invasion: A Prospective Study Examining Anatomic Site, Tumor Surface Diameter, Invasion Depth, and Grade of Differentiation in 1,772 Consecutive Cases
title Early Squamous Cell Carcinoma With Perineural Invasion: A Prospective Study Examining Anatomic Site, Tumor Surface Diameter, Invasion Depth, and Grade of Differentiation in 1,772 Consecutive Cases
title_full Early Squamous Cell Carcinoma With Perineural Invasion: A Prospective Study Examining Anatomic Site, Tumor Surface Diameter, Invasion Depth, and Grade of Differentiation in 1,772 Consecutive Cases
title_fullStr Early Squamous Cell Carcinoma With Perineural Invasion: A Prospective Study Examining Anatomic Site, Tumor Surface Diameter, Invasion Depth, and Grade of Differentiation in 1,772 Consecutive Cases
title_full_unstemmed Early Squamous Cell Carcinoma With Perineural Invasion: A Prospective Study Examining Anatomic Site, Tumor Surface Diameter, Invasion Depth, and Grade of Differentiation in 1,772 Consecutive Cases
title_short Early Squamous Cell Carcinoma With Perineural Invasion: A Prospective Study Examining Anatomic Site, Tumor Surface Diameter, Invasion Depth, and Grade of Differentiation in 1,772 Consecutive Cases
title_sort early squamous cell carcinoma with perineural invasion: a prospective study examining anatomic site, tumor surface diameter, invasion depth, and grade of differentiation in 1,772 consecutive cases
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319792/
https://www.ncbi.nlm.nih.gov/pubmed/32642309
http://dx.doi.org/10.5826/dpc.1003a59
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