Oncometabolites suppress DNA repair by disrupting local chromatin signaling

Deregulation of metabolism and disruption of genome integrity are hallmarks of cancer1. Elevated levels of the metabolites, 2-hydroxyglutarate (2HG), succinate, and fumarate, occur in human malignancies due to somatic mutations in the isocitrate dehydrogenase-1/2 (IDH1/2) genes or germline mutations...

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Detalles Bibliográficos
Autores principales: Sulkowski, Parker L., Oeck, Sebastian, Dow, Jonathan, Economos, Nicholas G., Mirfakhraie, Lily, Liu, Yanfeng, Noronha, Katelyn, Bao, Xun, Li, Jing, Shuch, Brian M., King, Megan C., Bindra, Ranjit S., Glazer, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319896/
https://www.ncbi.nlm.nih.gov/pubmed/32494005
http://dx.doi.org/10.1038/s41586-020-2363-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319896/
https://www.ncbi.nlm.nih.gov/pubmed/32494005
http://dx.doi.org/10.1038/s41586-020-2363-0

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