Cargando…

Oncometabolites suppress DNA repair by disrupting local chromatin signaling

Deregulation of metabolism and disruption of genome integrity are hallmarks of cancer1. Elevated levels of the metabolites, 2-hydroxyglutarate (2HG), succinate, and fumarate, occur in human malignancies due to somatic mutations in the isocitrate dehydrogenase-1/2 (IDH1/2) genes or germline mutations...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sulkowski, Parker L., Oeck, Sebastian, Dow, Jonathan, Economos, Nicholas G., Mirfakhraie, Lily, Liu, Yanfeng, Noronha, Katelyn, Bao, Xun, Li, Jing, Shuch, Brian M., King, Megan C., Bindra, Ranjit S., Glazer, Peter M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319896/ https://www.ncbi.nlm.nih.gov/pubmed/32494005 http://dx.doi.org/10.1038/s41586-020-2363-0

Ejemplares similares

Quantitative Profiling of Oncometabolites in Frozen and Formalin-Fixed Paraffin-Embedded Tissue Specimens by Liquid Chromatography Coupled with Tandem Mass Spectrometry
por: Bao, Xun, et al.
Publicado: (2019)

Krebs Cycle-Deficient Hereditary Cancer Syndromes are Defined by Homologous Recombination DNA Repair Defects
por: Sulkowski, Parker L., et al.
Publicado: (2018)

Oncometabolites and the response to radiotherapy
por: Xiang, Kexu, et al.
Publicado: (2020)

The emerging role of fumarate as an oncometabolite
por: Yang, Ming, et al.
Publicado: (2012)

Oncometabolites: tailoring our genes
por: Nowicki, Stefan, et al.
Publicado: (2015)

Kynurenine: an oncometabolite in colon cancer
por: Venkateswaran, Niranjan, et al.
Publicado: (2020)

Metabolic Rewiring and the Characterization of Oncometabolites
por: Beyoğlu, Diren, et al.
Publicado: (2021)

Oncometabolite induced primary cilia loss in pheochromocytoma
por: O’Toole, Samuel M, et al.
Publicado: (2018)

A chemoproteomic portrait of the oncometabolite fumarate
por: Kulkarni, Rhushikesh A., et al.
Publicado: (2019)

Oncometabolites: A new insight for oncology
por: Khatami, Fatemeh, et al.
Publicado: (2019)

SLC14A1 prevents oncometabolite accumulation and recruits HDAC1 to transrepress oncometabolite genes in urothelial carcinoma
por: Chan, Ti-Chun, et al.
Publicado: (2020)

Oncometabolites: Unconventional triggers of oncogenic signalling cascades
por: Sciacovelli, Marco, et al.
Publicado: (2016)

Oncometabolites as biomarkers in thyroid cancer: a systematic review
por: Khatami, Fatemeh, et al.
Publicado: (2019)

Clinical implications of the oncometabolite succinate in SDHx‐mutation carriers
por: Eijkelenkamp, Karin, et al.
Publicado: (2019)

Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d-2-Hydroxyglutarate
por: Fan, Jing, et al.
Publicado: (2014)

The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway
por: Carbonneau, Mélissa, et al.
Publicado: (2016)

Role of succinate dehydrogenase deficiency and oncometabolites in gastrointestinal stromal tumors
por: Zhao, Yue, et al.
Publicado: (2020)

Oncometabolites—A Link between Cancer Cells and Tumor Microenvironment
por: Baryła, Maksymilian, et al.
Publicado: (2022)

Targeting Oncometabolites in Peritoneal Cancers: Preclinical Insights and Therapeutic Strategies
por: Nadhan, Revathy, et al.
Publicado: (2023)

The Enzymology of 2-Hydroxyglutarate, 2-Hydroxyglutaramate and 2-Hydroxysuccinamate and Their Relationship to Oncometabolites
por: Hariharan, Vivek A., et al.
Publicado: (2017)

Oncometabolite modification of Keap1 links GSTZ1 deficiency with cancer
por: Guo, Weijie, et al.
Publicado: (2019)

Suppression of homology-dependent DNA double-strand break repair induces PARP inhibitor sensitivity in VHL-deficient human renal cell carcinoma
por: Scanlon, Susan E., et al.
Publicado: (2017)

Another small molecule in the oncometabolite mix: L-2-Hydroxyglutarate in kidney cancer
por: Shim, Eun-Hee, et al.
Publicado: (2015)

Changing perspective on oncometabolites: from metabolic signature of cancer to tumorigenic and immunosuppressive agents
por: Corrado, Mauro, et al.
Publicado: (2016)

Metabolic Alterations in Cancer Cells and the Emerging Role of Oncometabolites as Drivers of Neoplastic Change
por: Zhou, Zhengqiu, et al.
Publicado: (2018)

The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis
por: Wang, Tian-Xiang, et al.
Publicado: (2019)

Lactonization of the Oncometabolite D-2-Hydroxyglutarate Produces a Novel Endogenous Metabolite
por: Berger, Raffaela S., et al.
Publicado: (2021)

Targeting Mitochondrial Oncometabolites: A New Approach to Overcome Drug Resistance in Cancer
por: Godel, Martina, et al.
Publicado: (2021)

Mitochondrial DNA Stress Signalling Protects the Nuclear Genome
por: Wu, Zheng, et al.
Publicado: (2019)

Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate and promotes histone methylation
por: Fan, Jing, et al.
Publicado: (2014)

The Emerging Role of D-2-Hydroxyglutarate as an Oncometabolite in Hematolymphoid and Central Nervous System Neoplasms
por: Rakheja, Dinesh, et al.
Publicado: (2013)

From Metabolism to Genetics and Vice Versa: The Rising Role of Oncometabolites in Cancer Development and Therapy
por: Di Gregorio, Emanuela, et al.
Publicado: (2021)

Oncometabolites drive tumorigenesis by enhancing protein acylation: from chromosomal remodelling to nonhistone modification
por: Fu, Yidian, et al.
Publicado: (2022)

The role of FACT in managing chromatin: disruption, assembly, or repair?
por: Formosa, Tim, et al.
Publicado: (2020)

A Systems Approach to Predict Oncometabolites via Context-Specific Genome-Scale Metabolic Networks
por: Nam, Hojung, et al.
Publicado: (2014)

Registered report: Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
por: Evans, Brad, et al.
Publicado: (2015)

The Oncometabolite 5′-Deoxy-5′-Methylthioadenosine Blocks Multiple Signaling Pathways of NK Cell Activation
por: Jacobs, Benedikt, et al.
Publicado: (2020)

Imaging 2-hydroxyglutarate and other brain oncometabolites pertinent to critical genomic alterations in brain tumors
por: Thomas, Teena, et al.
Publicado: (2023)

Detection of Nail Oncometabolite SAICAR in Oral Cancer Patients and Its Molecular Interactions with PKM2 Enzyme
por: Patel, Rushikesh, et al.
Publicado: (2021)

GABPA-activated TGFBR2 transcription inhibits aggressiveness but is epigenetically erased by oncometabolites in renal cell carcinoma
por: Fang, Zhiqing, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vtf5q1g25gv3mss01q7g2lea6f