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The Development of Intestinal Dysbiosis in Anemic Preterm Infants

OBJECTIVE: Anemia and Proteobacteria-dominant intestinal dysbiosis in very low birth weight (VLBW) infants have been linked to necrotizing enterocolitis, a severe gut inflammatory disease. We hypothesize that anemia of prematurity is related to the development of intestinal dysbiosis. STUDY DESIGN:...

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Autores principales: Ho, Thao TB., Kumar, Ambuj, Louis-Jacques, Adetola F., Dishaw, Larry J., Yee, Alyson L., Groer, Maureen W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319903/
https://www.ncbi.nlm.nih.gov/pubmed/31992818
http://dx.doi.org/10.1038/s41372-020-0599-z
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author Ho, Thao TB.
Kumar, Ambuj
Louis-Jacques, Adetola F.
Dishaw, Larry J.
Yee, Alyson L.
Groer, Maureen W.
author_facet Ho, Thao TB.
Kumar, Ambuj
Louis-Jacques, Adetola F.
Dishaw, Larry J.
Yee, Alyson L.
Groer, Maureen W.
author_sort Ho, Thao TB.
collection PubMed
description OBJECTIVE: Anemia and Proteobacteria-dominant intestinal dysbiosis in very low birth weight (VLBW) infants have been linked to necrotizing enterocolitis, a severe gut inflammatory disease. We hypothesize that anemia of prematurity is related to the development of intestinal dysbiosis. STUDY DESIGN: 342 weekly stool samples collected prospectively from 80 VLBW infants were analyzed for bacterial microbiomes (with 16S rRNA). Linear mixed effects model was used to determine the relationships between the onsets of anemia and intestinal dysbiosis. RESULTS: Hematocrit was associated with intestinal microbiomes, with lower Hct occurring with increased Proteobacteria and decreased Firmicutes. Infants with a hematocrit <30% had intestinal microbiomes that diverged toward Proteobacteria dominance and low diversity after the first postnatal month. The microbiome changes were also related to the severity of anemia. CONCLUSIONS: This finding supports a potential microbiological explanation for anemia as a risk factor for intestinal dysbiosis in preterm infants.
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spelling pubmed-73199032020-07-28 The Development of Intestinal Dysbiosis in Anemic Preterm Infants Ho, Thao TB. Kumar, Ambuj Louis-Jacques, Adetola F. Dishaw, Larry J. Yee, Alyson L. Groer, Maureen W. J Perinatol Article OBJECTIVE: Anemia and Proteobacteria-dominant intestinal dysbiosis in very low birth weight (VLBW) infants have been linked to necrotizing enterocolitis, a severe gut inflammatory disease. We hypothesize that anemia of prematurity is related to the development of intestinal dysbiosis. STUDY DESIGN: 342 weekly stool samples collected prospectively from 80 VLBW infants were analyzed for bacterial microbiomes (with 16S rRNA). Linear mixed effects model was used to determine the relationships between the onsets of anemia and intestinal dysbiosis. RESULTS: Hematocrit was associated with intestinal microbiomes, with lower Hct occurring with increased Proteobacteria and decreased Firmicutes. Infants with a hematocrit <30% had intestinal microbiomes that diverged toward Proteobacteria dominance and low diversity after the first postnatal month. The microbiome changes were also related to the severity of anemia. CONCLUSIONS: This finding supports a potential microbiological explanation for anemia as a risk factor for intestinal dysbiosis in preterm infants. 2020-01-28 2020-07 /pmc/articles/PMC7319903/ /pubmed/31992818 http://dx.doi.org/10.1038/s41372-020-0599-z Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Ho, Thao TB.
Kumar, Ambuj
Louis-Jacques, Adetola F.
Dishaw, Larry J.
Yee, Alyson L.
Groer, Maureen W.
The Development of Intestinal Dysbiosis in Anemic Preterm Infants
title The Development of Intestinal Dysbiosis in Anemic Preterm Infants
title_full The Development of Intestinal Dysbiosis in Anemic Preterm Infants
title_fullStr The Development of Intestinal Dysbiosis in Anemic Preterm Infants
title_full_unstemmed The Development of Intestinal Dysbiosis in Anemic Preterm Infants
title_short The Development of Intestinal Dysbiosis in Anemic Preterm Infants
title_sort development of intestinal dysbiosis in anemic preterm infants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319903/
https://www.ncbi.nlm.nih.gov/pubmed/31992818
http://dx.doi.org/10.1038/s41372-020-0599-z
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