An alkaloid initiates phosphodiesterase 3A–schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity

The promotion of apoptosis in tumor cells is a popular strategy for developing anti-cancer drugs. Here, we demonstrate that the plant indole alkaloid natural product nauclefine induces apoptosis of diverse cancer cells via a PDE3A-SLFN12 dependent death pathway. Nauclefine binds PDE3A but does not i...

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Detalles Bibliográficos
Autores principales: Ai, Youwei, He, Haibing, Chen, Peihao, Yan, Bo, Zhang, Wenbin, Ding, Zhangcheng, Li, Dianrong, Chen, Jie, Ma, Yan, Cao, Yang, Zhu, Jie, Li, Jiaojiao, Ou, Jinjie, Du, Shan, Wang, Xiaodong, Ma, Jianzhang, Gao, Shuanhu, Qi, Xiangbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319972/
https://www.ncbi.nlm.nih.gov/pubmed/32591543
http://dx.doi.org/10.1038/s41467-020-17052-4

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