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Genetic drug target validation using Mendelian randomisation

Mendelian randomisation (MR) analysis is an important tool to elucidate the causal relevance of environmental and biological risk factors for disease. However, causal inference is undermined if genetic variants used to instrument a risk factor also influence alternative disease-pathways (horizontal...

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Detalles Bibliográficos
Autores principales:	Schmidt, Amand F., Finan, Chris, Gordillo-Marañón, Maria, Asselbergs, Folkert W., Freitag, Daniel F., Patel, Riyaz S., Tyl, Benoît, Chopade, Sandesh, Faraway, Rupert, Zwierzyna, Magdalena, Hingorani, Aroon D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320010/ https://www.ncbi.nlm.nih.gov/pubmed/32591531 http://dx.doi.org/10.1038/s41467-020-16969-0

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