Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation

In cancer, many genes are mutated by genome rearrangement, but our understanding of the functional consequences of this remains rudimentary. Here we report the F-box protein encoded by FBXL17 is disrupted in the region of the gene that encodes its substrate-binding leucine rich repeat (LRR) domain....

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Detalles Bibliográficos
Autores principales: Mason, Bethany, Flach, Susanne, Teixeira, Felipe R., Manzano Garcia, Raquel, Rueda, Oscar M., Abraham, Jean E., Caldas, Carlos, Edwards, Paul A. W., Laman, Heike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320043/
https://www.ncbi.nlm.nih.gov/pubmed/31560077
http://dx.doi.org/10.1007/s00018-019-03306-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320043/
https://www.ncbi.nlm.nih.gov/pubmed/31560077
http://dx.doi.org/10.1007/s00018-019-03306-y

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