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Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation
In cancer, many genes are mutated by genome rearrangement, but our understanding of the functional consequences of this remains rudimentary. Here we report the F-box protein encoded by FBXL17 is disrupted in the region of the gene that encodes its substrate-binding leucine rich repeat (LRR) domain....
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320043/ https://www.ncbi.nlm.nih.gov/pubmed/31560077 http://dx.doi.org/10.1007/s00018-019-03306-y |