Metabolic regulation of neurodifferentiation in the adult brain

Understanding the mechanisms behind neurodifferentiation in adults will be an important milestone in our quest to identify treatment strategies for cognitive disorders observed during our natural ageing or disease. It is now clear that the maturation of neural stem cells to neurones, fully integrate...

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Autores principales: Maffezzini, Camilla, Calvo-Garrido, Javier, Wredenberg, Anna, Freyer, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320050/
https://www.ncbi.nlm.nih.gov/pubmed/31912194
http://dx.doi.org/10.1007/s00018-019-03430-9
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author Maffezzini, Camilla
Calvo-Garrido, Javier
Wredenberg, Anna
Freyer, Christoph
author_facet Maffezzini, Camilla
Calvo-Garrido, Javier
Wredenberg, Anna
Freyer, Christoph
author_sort Maffezzini, Camilla
collection PubMed
description Understanding the mechanisms behind neurodifferentiation in adults will be an important milestone in our quest to identify treatment strategies for cognitive disorders observed during our natural ageing or disease. It is now clear that the maturation of neural stem cells to neurones, fully integrated into neuronal circuits requires a complete remodelling of cellular metabolism, including switching the cellular energy source. Mitochondria are central for this transition and are increasingly seen as the regulatory hub in defining neural stem cell fate and neurodevelopment. This review explores our current knowledge of metabolism during adult neurodifferentiation.
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spelling pubmed-73200502020-07-01 Metabolic regulation of neurodifferentiation in the adult brain Maffezzini, Camilla Calvo-Garrido, Javier Wredenberg, Anna Freyer, Christoph Cell Mol Life Sci Review Understanding the mechanisms behind neurodifferentiation in adults will be an important milestone in our quest to identify treatment strategies for cognitive disorders observed during our natural ageing or disease. It is now clear that the maturation of neural stem cells to neurones, fully integrated into neuronal circuits requires a complete remodelling of cellular metabolism, including switching the cellular energy source. Mitochondria are central for this transition and are increasingly seen as the regulatory hub in defining neural stem cell fate and neurodevelopment. This review explores our current knowledge of metabolism during adult neurodifferentiation. Springer International Publishing 2020-01-07 2020 /pmc/articles/PMC7320050/ /pubmed/31912194 http://dx.doi.org/10.1007/s00018-019-03430-9 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Maffezzini, Camilla
Calvo-Garrido, Javier
Wredenberg, Anna
Freyer, Christoph
Metabolic regulation of neurodifferentiation in the adult brain
title Metabolic regulation of neurodifferentiation in the adult brain
title_full Metabolic regulation of neurodifferentiation in the adult brain
title_fullStr Metabolic regulation of neurodifferentiation in the adult brain
title_full_unstemmed Metabolic regulation of neurodifferentiation in the adult brain
title_short Metabolic regulation of neurodifferentiation in the adult brain
title_sort metabolic regulation of neurodifferentiation in the adult brain
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320050/
https://www.ncbi.nlm.nih.gov/pubmed/31912194
http://dx.doi.org/10.1007/s00018-019-03430-9
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