NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation

BRCA1 mutation carriers have a higher risk of developing triple-negative breast cancer (TNBC), which is a refractory disease due to its non-responsiveness to current clinical targeted therapies. Using the Sleeping Beauty transposon system in Brca1-deficient mice, we identified 169 putative cancer dr...

Descripción completa

Detalles Bibliográficos
Autores principales: Miao, Kai, Lei, Josh Haipeng, Valecha, Monica Vishnu, Zhang, Aiping, Xu, Jun, Wang, Lijian, Lyu, Xueying, Chen, Si, Miao, Zhengqiang, Zhang, Xin, Su, Sek Man, Shao, Fangyuan, Rajendran, Barani Kumar, Bao, Jiaolin, Zeng, Jianming, Sun, Heng, Chen, Ping, Tan, Kaeling, Chen, Qiang, Wong, Koon Ho, Xu, Xiaoling, Deng, Chu-Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320176/
https://www.ncbi.nlm.nih.gov/pubmed/32591500
http://dx.doi.org/10.1038/s41467-020-16936-9

Ejemplares similares

Ejemplares similares