Cargando…

Prioritization of causal genes for coronary artery disease based on cumulative evidence from experimental and in silico studies

Genome-wide association studies have led to a significant progress in identification of genomic loci affecting coronary artery disease (CAD) risk. However, revealing the causal genes responsible for the observed associations is challenging. In the present study, we aimed to prioritize CAD-relevant g...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shadrina, Alexandra S., Shashkova, Tatiana I., Torgasheva, Anna A., Sharapov, Sodbo Z., Klarić, Lucija, Pakhomov, Eugene D., Alexeev, Dmitry G., Wilson, James F., Tsepilov, Yakov A., Joshi, Peter K., Aulchenko, Yurii S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320185/ https://www.ncbi.nlm.nih.gov/pubmed/32591598 http://dx.doi.org/10.1038/s41598-020-67001-w

Ejemplares similares

Varicose veins of lower extremities: Insights from the first large-scale genetic study
por: Shadrina, Alexandra S., et al.
Publicado: (2019)

Identification of 12 genetic loci associated with human healthspan
por: Zenin, Aleksandr, et al.
Publicado: (2019)

The GWAS-MAP platform for aggregation of results of genome-wide association studies and the GWAS-MAP|homo database of 70 billion genetic associations of human traits
por: Shashkova, T.I., et al.
Publicado: (2020)

Genetic regulation of post-translational modification of two distinct proteins
por: Landini, Arianna, et al.
Publicado: (2022)

Analysis of genetically independent phenotypes identifies shared genetic factors associated with chronic musculoskeletal pain conditions
por: Tsepilov, Yakov A., et al.
Publicado: (2020)

PheLiGe: an interactive database of billions of human genotype–phenotype associations
por: Shashkova, Tatiana I, et al.
Publicado: (2020)

Nontrivial Replication of Loci Detected by Multi-Trait Methods
por: Ning, Zheng, et al.
Publicado: (2021)

High-Performance Mixed Models Based Genome-Wide Association Analysis with omicABEL software
por: Fabregat-Traver, Diego, et al.
Publicado: (2014)

Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation
por: Shen, Xia, et al.
Publicado: (2017)

A Novel Framework for Analysis of the Shared Genetic Background of Correlated Traits
por: Svishcheva, Gulnara R., et al.
Publicado: (2022)

Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain
por: Rahman, Md Shafiqur, et al.
Publicado: (2021)

Development and Application of Genomic Control Methods for Genome-Wide Association Studies Using Non-Additive Models
por: Tsepilov, Yakov A., et al.
Publicado: (2013)

A protocol for recruiting and analyzing the disease-oriented Russian disc degeneration study (RuDDS) biobank for functional omics studies of lumbar disc degeneration
por: Leonova, Olga N., et al.
Publicado: (2022)

Method for the Isolation of “RNA-seq-Quality” RNA from Human Intervertebral Discs after Mortar and Pestle Homogenization
por: Ivanov, Artemii A., et al.
Publicado: (2022)

Interbreed variation in meiotic recombination rate and distribution in the domestic chicken Gallus gallus
por: Malinovskaya, Lyubov P., et al.
Publicado: (2019)

Association Between Human Gut Microbiome and N-Glycan Composition of Total Plasma Proteome
por: Petrov, Vyacheslav A., et al.
Publicado: (2022)

The limits of normal approximation for adult height
por: Slavskii, Sergei A., et al.
Publicado: (2021)

Decision prioritization and causal reasoning in decision hierarchies
por: Zylberberg, Ariel
Publicado: (2021)

Associations Between Genetically Predicted Plasma N-Glycans and Prostate Cancer Risk: Analysis of Over 140,000 European Descendants
por: Liu, Duo, et al.
Publicado: (2021)

A network-based conditional genetic association analysis of the human metabolome
por: Tsepilov, Y A, et al.
Publicado: (2018)

Correction to: A network-based conditional genetic association analysis of the human metabolome
por: Tsepilov, Y A, et al.
Publicado: (2019)

In-silico identification and prioritization of therapeutic targets of asthma
por: Mallick, Ishita, et al.
Publicado: (2023)

Development and Replication of a Genome-Wide Polygenic Risk Score for Chronic Back Pain
por: Tsepilov, Yakov A., et al.
Publicado: (2023)

Agent Based Modeling of Human Gut Microbiome Interactions and Perturbations
por: Shashkova, Tatiana, et al.
Publicado: (2016)

The GWAS-MAP|ovis platform for aggregation and analysis of genome-wide association study results in sheep
por: A.V. Kirichenko, A.V., et al.
Publicado: (2022)

Genetic control of N-glycosylation of human blood plasma proteins
por: Sharapov, S.Zh., et al.
Publicado: (2023)

Prioritizing causal disease genes using unbiased genomic features
por: Deo, Rahul C, et al.
Publicado: (2014)

Modeling Cumulative Biological Phenomena with Suppes-Bayes Causal Networks
por: Ramazzotti, Daniele, et al.
Publicado: (2018)

Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases
por: Klarić, Lucija, et al.
Publicado: (2020)

In Silico Gene Prioritization by Integrating Multiple Data Sources
por: Chen, Yixuan, et al.
Publicado: (2011)

Gene-based association analysis identifies 190 genes affecting neuroticism
por: Belonogova, Nadezhda M., et al.
Publicado: (2021)

Mendelian randomization analysis of plasma levels of CD209 and MICB proteins and the risk of varicose veins of lower extremities
por: Shadrina, Alexandra S., et al.
Publicado: (2022)

Prioritization of Mycotoxins Based on Their Genotoxic Potential with an In Silico-In Vitro Strategy
por: Alonso-Jauregui, Maria, et al.
Publicado: (2021)

Recent advances in understanding genetic variants associated with growth, carcass and meat productivity traits in sheep (Ovis aries): an update
por: Zlobin, Alexander S., et al.
Publicado: (2019)

Integrating Functional Data to Prioritize Causal Variants in Statistical Fine-Mapping Studies
por: Kichaev, Gleb, et al.
Publicado: (2014)

Prioritized candidate causal haplotype blocks in plant genome-wide association studies
por: Wu, Xing, et al.
Publicado: (2022)

Prioritizing candidate eQTL causal genes in Arabidopsis using RANDOM FORESTS
por: Hartanto, Margi, et al.
Publicado: (2022)

In silico Prioritization of Transporter–Drug Relationships From Drug Sensitivity Screens
por: César-Razquin, Adrián, et al.
Publicado: (2018)

In silico prioritization and further functional characterization of SPINK1 intronic variants
por: Zou, Wen-Bin, et al.
Publicado: (2017)

Identification of tissue-specific and common methylation quantitative trait loci in healthy individuals using MAGAR
por: Scherer, Michael, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_0hl7fe0h93khrpuovfasu8bdbe