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Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases

During the aging process, senescent cells gradually accumulate in the organs; they secrete proinflammatory cytokines and other factors, collectively known as the senescence-associated secretory phenotype (SASP). SASP secretions contribute to “inflammaging,” which is a state of chronic, systemic, ste...

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Autores principales: Zhou, Yi-Ting, Zhu, Lin, Yuan, Yunyun, Ling, Shuang, Xu, Jin-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320294/
https://www.ncbi.nlm.nih.gov/pubmed/32655760
http://dx.doi.org/10.1155/2020/2128513
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author Zhou, Yi-Ting
Zhu, Lin
Yuan, Yunyun
Ling, Shuang
Xu, Jin-Wen
author_facet Zhou, Yi-Ting
Zhu, Lin
Yuan, Yunyun
Ling, Shuang
Xu, Jin-Wen
author_sort Zhou, Yi-Ting
collection PubMed
description During the aging process, senescent cells gradually accumulate in the organs; they secrete proinflammatory cytokines and other factors, collectively known as the senescence-associated secretory phenotype (SASP). SASP secretions contribute to “inflammaging,” which is a state of chronic, systemic, sterility, low-grade inflammatory microenvironment and a key risk factor in the development of aging-related diseases. Fructus psoraleae is a traditional Chinese medical herb best known for delaying aging and treating osteoporosis. Prenylflavonoids from fructus psoraleae are the main bioactive compounds responsible for its pharmacological applications, such as beaching, bavachinin, bavachalcone, isobavachalcone, and neobavaisoflavone. In previous decades, there have been some promising studies on the pharmacology of fructus psoraleae. Here, we focus on the anti-inflammatory and antiaging diseases of five psoralea prenylflavonoids, such as cardiovascular protection, diabetes and obesity intervention, neuroprotection, and osteoporosis, and discuss the mechanism of these active ingredients for better understanding the material basis and drug application of fructus psoraleae in Chinese medicine.
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spelling pubmed-73202942020-07-11 Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases Zhou, Yi-Ting Zhu, Lin Yuan, Yunyun Ling, Shuang Xu, Jin-Wen Oxid Med Cell Longev Review Article During the aging process, senescent cells gradually accumulate in the organs; they secrete proinflammatory cytokines and other factors, collectively known as the senescence-associated secretory phenotype (SASP). SASP secretions contribute to “inflammaging,” which is a state of chronic, systemic, sterility, low-grade inflammatory microenvironment and a key risk factor in the development of aging-related diseases. Fructus psoraleae is a traditional Chinese medical herb best known for delaying aging and treating osteoporosis. Prenylflavonoids from fructus psoraleae are the main bioactive compounds responsible for its pharmacological applications, such as beaching, bavachinin, bavachalcone, isobavachalcone, and neobavaisoflavone. In previous decades, there have been some promising studies on the pharmacology of fructus psoraleae. Here, we focus on the anti-inflammatory and antiaging diseases of five psoralea prenylflavonoids, such as cardiovascular protection, diabetes and obesity intervention, neuroprotection, and osteoporosis, and discuss the mechanism of these active ingredients for better understanding the material basis and drug application of fructus psoraleae in Chinese medicine. Hindawi 2020-06-17 /pmc/articles/PMC7320294/ /pubmed/32655760 http://dx.doi.org/10.1155/2020/2128513 Text en Copyright © 2020 Yi-Ting Zhou et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhou, Yi-Ting
Zhu, Lin
Yuan, Yunyun
Ling, Shuang
Xu, Jin-Wen
Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases
title Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases
title_full Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases
title_fullStr Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases
title_full_unstemmed Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases
title_short Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases
title_sort effects and mechanisms of five psoralea prenylflavonoids on aging-related diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320294/
https://www.ncbi.nlm.nih.gov/pubmed/32655760
http://dx.doi.org/10.1155/2020/2128513
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