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Measuring the accuracy of a point system to diagnose tuberculosis in children with a negative smear or with no smear or culture
In Brazil, a scoring system was adopted to diagnose tuberculosis in childhood. This study determined the accuracy in diagnosing tuberculosis in children with either a negative smear or with no smear or culture conducted in a reference center in João Pessoa Paraíba – Brazil. It is a phase III validat...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Atlantis Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320401/ https://www.ncbi.nlm.nih.gov/pubmed/24534333 http://dx.doi.org/10.1016/j.jegh.2013.10.002 |
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author | Braga Cartaxo, Constantino Giovani Rodrigues, Laura C. Braga, Carolina Pinheiro de Alencar Ximenes, Ricardo Arraes |
author_facet | Braga Cartaxo, Constantino Giovani Rodrigues, Laura C. Braga, Carolina Pinheiro de Alencar Ximenes, Ricardo Arraes |
author_sort | Braga Cartaxo, Constantino Giovani |
collection | PubMed |
description | In Brazil, a scoring system was adopted to diagnose tuberculosis in childhood. This study determined the accuracy in diagnosing tuberculosis in children with either a negative smear or with no smear or culture conducted in a reference center in João Pessoa Paraíba – Brazil. It is a phase III validation study, using a cross-section design. The study population consisted of 167 patients attending the outpatient clinics suspected of having tuberculosis. The reference standard for the diagnosis of tuberculosis was a blind and independent review of the medical records, radiology and tuberculin test by two experts. Of the 167 patients, 60 were considered to have tuberculosis (by the reference standard diagnostics). The results for the scoring system with the cut-off of 30 points were: sensitivity 78.57% (95%-CI: 65.56–88.41%), specificity 69.16% (95%-CI: 59.50–77.73%), positive predictive value (PPV): 57.14% (95%-CI: 45.35–68.37%), negative predictive value (NPV): 86.05% (95%-CI: 76.89–92.58%), likelihood ratio (+): 2,55, pre-test probability: 34.36%, and post-test probability (+): 57.14%. This supports the current recommendation for the use of this scoring system in Brazil and similar sites with the cut-off of 30 points. However, as the discriminatory power of the point scoring system may vary across settings, it would be advisable to replicate this phase III study in different settings. |
format | Online Article Text |
id | pubmed-7320401 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Atlantis Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-73204012020-07-28 Measuring the accuracy of a point system to diagnose tuberculosis in children with a negative smear or with no smear or culture Braga Cartaxo, Constantino Giovani Rodrigues, Laura C. Braga, Carolina Pinheiro de Alencar Ximenes, Ricardo Arraes J Epidemiol Glob Health Article In Brazil, a scoring system was adopted to diagnose tuberculosis in childhood. This study determined the accuracy in diagnosing tuberculosis in children with either a negative smear or with no smear or culture conducted in a reference center in João Pessoa Paraíba – Brazil. It is a phase III validation study, using a cross-section design. The study population consisted of 167 patients attending the outpatient clinics suspected of having tuberculosis. The reference standard for the diagnosis of tuberculosis was a blind and independent review of the medical records, radiology and tuberculin test by two experts. Of the 167 patients, 60 were considered to have tuberculosis (by the reference standard diagnostics). The results for the scoring system with the cut-off of 30 points were: sensitivity 78.57% (95%-CI: 65.56–88.41%), specificity 69.16% (95%-CI: 59.50–77.73%), positive predictive value (PPV): 57.14% (95%-CI: 45.35–68.37%), negative predictive value (NPV): 86.05% (95%-CI: 76.89–92.58%), likelihood ratio (+): 2,55, pre-test probability: 34.36%, and post-test probability (+): 57.14%. This supports the current recommendation for the use of this scoring system in Brazil and similar sites with the cut-off of 30 points. However, as the discriminatory power of the point scoring system may vary across settings, it would be advisable to replicate this phase III study in different settings. Atlantis Press 2014 2013-11-15 /pmc/articles/PMC7320401/ /pubmed/24534333 http://dx.doi.org/10.1016/j.jegh.2013.10.002 Text en © 2013 Ministry of Health, Saudi Arabia. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Braga Cartaxo, Constantino Giovani Rodrigues, Laura C. Braga, Carolina Pinheiro de Alencar Ximenes, Ricardo Arraes Measuring the accuracy of a point system to diagnose tuberculosis in children with a negative smear or with no smear or culture |
title | Measuring the accuracy of a point system to diagnose tuberculosis in children with a negative smear or with no smear or culture |
title_full | Measuring the accuracy of a point system to diagnose tuberculosis in children with a negative smear or with no smear or culture |
title_fullStr | Measuring the accuracy of a point system to diagnose tuberculosis in children with a negative smear or with no smear or culture |
title_full_unstemmed | Measuring the accuracy of a point system to diagnose tuberculosis in children with a negative smear or with no smear or culture |
title_short | Measuring the accuracy of a point system to diagnose tuberculosis in children with a negative smear or with no smear or culture |
title_sort | measuring the accuracy of a point system to diagnose tuberculosis in children with a negative smear or with no smear or culture |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320401/ https://www.ncbi.nlm.nih.gov/pubmed/24534333 http://dx.doi.org/10.1016/j.jegh.2013.10.002 |
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