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Epidemiology, clinical manifestations, and molecular typing of salmonella typhi isolated from patients with typhoid fever in Lebanon
The objective of this study was to examine the epidemiology and the clinical manifestations of typhoid fever as well as the susceptibility and strain relatedness of Salmonella typhi isolates in Lebanon from 2006 to 2007. A total of 120 patients with typhoid fever were initially identified from vario...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Atlantis Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320491/ https://www.ncbi.nlm.nih.gov/pubmed/25922325 http://dx.doi.org/10.1016/j.jegh.2014.07.003 |
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author | Kanj, Souha S. Kanafani, Zeina A. Shehab, Marwa Sidani, Nisreen Baban, Tania Baltajian, Kedak Dakdouki, Ghenwa K. Zaatari, Mohamad Araj, George F. Wakim, Rima Hanna Dbaibo, Ghassan Matar, Ghassan M. |
author_facet | Kanj, Souha S. Kanafani, Zeina A. Shehab, Marwa Sidani, Nisreen Baban, Tania Baltajian, Kedak Dakdouki, Ghenwa K. Zaatari, Mohamad Araj, George F. Wakim, Rima Hanna Dbaibo, Ghassan Matar, Ghassan M. |
author_sort | Kanj, Souha S. |
collection | PubMed |
description | The objective of this study was to examine the epidemiology and the clinical manifestations of typhoid fever as well as the susceptibility and strain relatedness of Salmonella typhi isolates in Lebanon from 2006 to 2007. A total of 120 patients with typhoid fever were initially identified from various areas of the country based on positive culture results for S. typhi from blood, urine, stools, bone marrow and/or positive serology. Clinical, microbiological and molecular analysis was performed on cases with complete data available. These results indicated that drinking water was an unlikely mode of transmission of the infection. Despite increasing reports of antimicrobial resistance among S. typhi isolates, the vast majority of these isolates were susceptible to various antibiotic agents, including ampicillin, cephalosporins, quinolones, and trimethoprim/sulfamethoxazole. Molecular analysis of the isolates revealed a predominance of one single genotype with no variation in distribution across the geographical regions. |
format | Online Article Text |
id | pubmed-7320491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Atlantis Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-73204912020-07-28 Epidemiology, clinical manifestations, and molecular typing of salmonella typhi isolated from patients with typhoid fever in Lebanon Kanj, Souha S. Kanafani, Zeina A. Shehab, Marwa Sidani, Nisreen Baban, Tania Baltajian, Kedak Dakdouki, Ghenwa K. Zaatari, Mohamad Araj, George F. Wakim, Rima Hanna Dbaibo, Ghassan Matar, Ghassan M. J Epidemiol Glob Health Article The objective of this study was to examine the epidemiology and the clinical manifestations of typhoid fever as well as the susceptibility and strain relatedness of Salmonella typhi isolates in Lebanon from 2006 to 2007. A total of 120 patients with typhoid fever were initially identified from various areas of the country based on positive culture results for S. typhi from blood, urine, stools, bone marrow and/or positive serology. Clinical, microbiological and molecular analysis was performed on cases with complete data available. These results indicated that drinking water was an unlikely mode of transmission of the infection. Despite increasing reports of antimicrobial resistance among S. typhi isolates, the vast majority of these isolates were susceptible to various antibiotic agents, including ampicillin, cephalosporins, quinolones, and trimethoprim/sulfamethoxazole. Molecular analysis of the isolates revealed a predominance of one single genotype with no variation in distribution across the geographical regions. Atlantis Press 2015 2014-09-10 /pmc/articles/PMC7320491/ /pubmed/25922325 http://dx.doi.org/10.1016/j.jegh.2014.07.003 Text en © 2014 Ministry of Health, Saudi Arabia. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Kanj, Souha S. Kanafani, Zeina A. Shehab, Marwa Sidani, Nisreen Baban, Tania Baltajian, Kedak Dakdouki, Ghenwa K. Zaatari, Mohamad Araj, George F. Wakim, Rima Hanna Dbaibo, Ghassan Matar, Ghassan M. Epidemiology, clinical manifestations, and molecular typing of salmonella typhi isolated from patients with typhoid fever in Lebanon |
title | Epidemiology, clinical manifestations, and molecular typing of salmonella typhi isolated from patients with typhoid fever in Lebanon |
title_full | Epidemiology, clinical manifestations, and molecular typing of salmonella typhi isolated from patients with typhoid fever in Lebanon |
title_fullStr | Epidemiology, clinical manifestations, and molecular typing of salmonella typhi isolated from patients with typhoid fever in Lebanon |
title_full_unstemmed | Epidemiology, clinical manifestations, and molecular typing of salmonella typhi isolated from patients with typhoid fever in Lebanon |
title_short | Epidemiology, clinical manifestations, and molecular typing of salmonella typhi isolated from patients with typhoid fever in Lebanon |
title_sort | epidemiology, clinical manifestations, and molecular typing of salmonella typhi isolated from patients with typhoid fever in lebanon |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320491/ https://www.ncbi.nlm.nih.gov/pubmed/25922325 http://dx.doi.org/10.1016/j.jegh.2014.07.003 |
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