Association of lipoprotein lipase gene with coronary heart disease in Sudanese population

Cardiovascular disease is stabilizing in high-income countries and has continued to rise in low-to-middle-income countries. Association of lipid profile with lipoprotein lipase gene was studied in case and control subject. The family history, hypertension, diabetes mellitus, smoking and alcohol cons...

Descripción completa

Detalles Bibliográficos
Autores principales: Abdel Hamid, Muzamil M., Ahmed, Safa, Salah, Awatif, Tyrab, Etayeb M.A., Yahia, Lemya M., Elbashir, Elbagire A., Musa, Hassan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Atlantis Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320496/
https://www.ncbi.nlm.nih.gov/pubmed/26025183
http://dx.doi.org/10.1016/j.jegh.2015.04.007
_version_ 1783551253508259840
author Abdel Hamid, Muzamil M.
Ahmed, Safa
Salah, Awatif
Tyrab, Etayeb M.A.
Yahia, Lemya M.
Elbashir, Elbagire A.
Musa, Hassan H.
author_facet Abdel Hamid, Muzamil M.
Ahmed, Safa
Salah, Awatif
Tyrab, Etayeb M.A.
Yahia, Lemya M.
Elbashir, Elbagire A.
Musa, Hassan H.
author_sort Abdel Hamid, Muzamil M.
collection PubMed
description Cardiovascular disease is stabilizing in high-income countries and has continued to rise in low-to-middle-income countries. Association of lipid profile with lipoprotein lipase gene was studied in case and control subject. The family history, hypertension, diabetes mellitus, smoking and alcohol consumption were the most risk factors for early-onset of coronary heart disease (CHD). Sudanese patients had significantly (P < 0.05) lower TC and LDL-C levels compared to controls. Allele frequency of LPL D9N, N291S and S447X carrier genotype was 4.2%, 30.7% and 7.1%, respectively. We conclude that lipoprotein lipase polymorphism was not associated with the incidence of CHD in Sudan.
format Online
Article
Text
id pubmed-7320496
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Atlantis Press
record_format MEDLINE/PubMed
spelling pubmed-73204962020-07-28 Association of lipoprotein lipase gene with coronary heart disease in Sudanese population Abdel Hamid, Muzamil M. Ahmed, Safa Salah, Awatif Tyrab, Etayeb M.A. Yahia, Lemya M. Elbashir, Elbagire A. Musa, Hassan H. J Epidemiol Glob Health Article Cardiovascular disease is stabilizing in high-income countries and has continued to rise in low-to-middle-income countries. Association of lipid profile with lipoprotein lipase gene was studied in case and control subject. The family history, hypertension, diabetes mellitus, smoking and alcohol consumption were the most risk factors for early-onset of coronary heart disease (CHD). Sudanese patients had significantly (P < 0.05) lower TC and LDL-C levels compared to controls. Allele frequency of LPL D9N, N291S and S447X carrier genotype was 4.2%, 30.7% and 7.1%, respectively. We conclude that lipoprotein lipase polymorphism was not associated with the incidence of CHD in Sudan. Atlantis Press 2015 2015-05-27 /pmc/articles/PMC7320496/ /pubmed/26025183 http://dx.doi.org/10.1016/j.jegh.2015.04.007 Text en © 2015 Ministry of Health, Saudi Arabia. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Abdel Hamid, Muzamil M.
Ahmed, Safa
Salah, Awatif
Tyrab, Etayeb M.A.
Yahia, Lemya M.
Elbashir, Elbagire A.
Musa, Hassan H.
Association of lipoprotein lipase gene with coronary heart disease in Sudanese population
title Association of lipoprotein lipase gene with coronary heart disease in Sudanese population
title_full Association of lipoprotein lipase gene with coronary heart disease in Sudanese population
title_fullStr Association of lipoprotein lipase gene with coronary heart disease in Sudanese population
title_full_unstemmed Association of lipoprotein lipase gene with coronary heart disease in Sudanese population
title_short Association of lipoprotein lipase gene with coronary heart disease in Sudanese population
title_sort association of lipoprotein lipase gene with coronary heart disease in sudanese population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320496/
https://www.ncbi.nlm.nih.gov/pubmed/26025183
http://dx.doi.org/10.1016/j.jegh.2015.04.007
work_keys_str_mv AT abdelhamidmuzamilm associationoflipoproteinlipasegenewithcoronaryheartdiseaseinsudanesepopulation
AT ahmedsafa associationoflipoproteinlipasegenewithcoronaryheartdiseaseinsudanesepopulation
AT salahawatif associationoflipoproteinlipasegenewithcoronaryheartdiseaseinsudanesepopulation
AT tyrabetayebma associationoflipoproteinlipasegenewithcoronaryheartdiseaseinsudanesepopulation
AT yahialemyam associationoflipoproteinlipasegenewithcoronaryheartdiseaseinsudanesepopulation
AT elbashirelbagirea associationoflipoproteinlipasegenewithcoronaryheartdiseaseinsudanesepopulation
AT musahassanh associationoflipoproteinlipasegenewithcoronaryheartdiseaseinsudanesepopulation

Ejemplares similares