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Impact of surgical strategies on the survival of gallbladder cancer patients: analysis of 715 cases

OBJECTIVE: The aim of the study is to evaluate the impact of application of surgical strategies at different cancer stages on the survival of gallbladder cancer (GBC) patients. METHODS: The patients with GBC were divided into 3 groups according to their received surgical strategies: simple resection...

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Autores principales: Chang, Yigang, Li, Qiang, Wu, Qian, Chi, Limin, Bi, Xiaogang, Zeng, Qingmin, Huo, Huaying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320575/
https://www.ncbi.nlm.nih.gov/pubmed/32590998
http://dx.doi.org/10.1186/s12957-020-01915-7
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author Chang, Yigang
Li, Qiang
Wu, Qian
Chi, Limin
Bi, Xiaogang
Zeng, Qingmin
Huo, Huaying
author_facet Chang, Yigang
Li, Qiang
Wu, Qian
Chi, Limin
Bi, Xiaogang
Zeng, Qingmin
Huo, Huaying
author_sort Chang, Yigang
collection PubMed
description OBJECTIVE: The aim of the study is to evaluate the impact of application of surgical strategies at different cancer stages on the survival of gallbladder cancer (GBC) patients. METHODS: The patients with GBC were divided into 3 groups according to their received surgical strategies: simple resection (full-thickness cholecystectomy for removal of primary tumor site), radical resection (gallbladder bed removal combined with partial hepatectomy), and palliative surgery (treatment at advanced stages). The overall survival (OS) of GBC patients who were received different surgical strategies was compared. RESULTS: Survival analysis showed that radical resection had a best OS at clinical stage II, and simple resection had a best OS at tumor clinical stage IV. Cox hazard proportional regression analysis showed that more advanced tumor stages, tumor location of gallbladder body or neck, and CA199 ≥ 27 U/mL were the major risk factors for the OS of GBC. CONCLUSIONS: At tumor stage II, radical resection should be the most effective surgical therapy for GBC. However, the effect of radical resection at advanced stages could be restricted. The utilization of radical resection should be increased at tumor stage II for a better long-term survival outcome.
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spelling pubmed-73205752020-06-29 Impact of surgical strategies on the survival of gallbladder cancer patients: analysis of 715 cases Chang, Yigang Li, Qiang Wu, Qian Chi, Limin Bi, Xiaogang Zeng, Qingmin Huo, Huaying World J Surg Oncol Research OBJECTIVE: The aim of the study is to evaluate the impact of application of surgical strategies at different cancer stages on the survival of gallbladder cancer (GBC) patients. METHODS: The patients with GBC were divided into 3 groups according to their received surgical strategies: simple resection (full-thickness cholecystectomy for removal of primary tumor site), radical resection (gallbladder bed removal combined with partial hepatectomy), and palliative surgery (treatment at advanced stages). The overall survival (OS) of GBC patients who were received different surgical strategies was compared. RESULTS: Survival analysis showed that radical resection had a best OS at clinical stage II, and simple resection had a best OS at tumor clinical stage IV. Cox hazard proportional regression analysis showed that more advanced tumor stages, tumor location of gallbladder body or neck, and CA199 ≥ 27 U/mL were the major risk factors for the OS of GBC. CONCLUSIONS: At tumor stage II, radical resection should be the most effective surgical therapy for GBC. However, the effect of radical resection at advanced stages could be restricted. The utilization of radical resection should be increased at tumor stage II for a better long-term survival outcome. BioMed Central 2020-06-26 /pmc/articles/PMC7320575/ /pubmed/32590998 http://dx.doi.org/10.1186/s12957-020-01915-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Chang, Yigang
Li, Qiang
Wu, Qian
Chi, Limin
Bi, Xiaogang
Zeng, Qingmin
Huo, Huaying
Impact of surgical strategies on the survival of gallbladder cancer patients: analysis of 715 cases
title Impact of surgical strategies on the survival of gallbladder cancer patients: analysis of 715 cases
title_full Impact of surgical strategies on the survival of gallbladder cancer patients: analysis of 715 cases
title_fullStr Impact of surgical strategies on the survival of gallbladder cancer patients: analysis of 715 cases
title_full_unstemmed Impact of surgical strategies on the survival of gallbladder cancer patients: analysis of 715 cases
title_short Impact of surgical strategies on the survival of gallbladder cancer patients: analysis of 715 cases
title_sort impact of surgical strategies on the survival of gallbladder cancer patients: analysis of 715 cases
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320575/
https://www.ncbi.nlm.nih.gov/pubmed/32590998
http://dx.doi.org/10.1186/s12957-020-01915-7
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