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Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma

OBJECTIVE: Natural killer (NK) cells play a critical role in the innate antitumor immune response. Recently, NK cell dysfunction has been verified in various malignant tumors, including hepatocellular carcinoma (HCC). However, the molecular biological mechanisms of NK cell dysfunction in human HCC a...

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Detalles Bibliográficos
Autores principales:	Zhang, Peng-Fei, Gao, Chao, Huang, Xiao-Yong, Lu, Jia-Cheng, Guo, Xiao-Jun, Shi, Guo-Ming, Cai, Jia-Bin, Ke, Ai-Wu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320583/ https://www.ncbi.nlm.nih.gov/pubmed/32593303 http://dx.doi.org/10.1186/s12943-020-01222-5

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