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Evaluating the Effect of Cryptorchidism on Clinical Stage of Testicular Seminoma

OBJECTIVE: To study the effect of cryptorchidism on clinical stage (CS) of testicular seminoma (TS). PATIENTS AND METHODS: In the Surveillance Epidemiology and End Results (SEER) database (2006‐2016), people with TS were enrolled in our research. Multivariable logistic regression models were constru...

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Autores principales: Wang, Xingyuan, Chen, Zeyu, Qiu, Shi, Cao, Dehong, Jin, Kun, Li, Jin, Chen, Bo, Huang, Yin, Bao, Yige, Liu, Liangren, Wei, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320749/
https://www.ncbi.nlm.nih.gov/pubmed/32606976
http://dx.doi.org/10.2147/CMAR.S236618
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author Wang, Xingyuan
Chen, Zeyu
Qiu, Shi
Cao, Dehong
Jin, Kun
Li, Jin
Chen, Bo
Huang, Yin
Bao, Yige
Liu, Liangren
Wei, Qiang
author_facet Wang, Xingyuan
Chen, Zeyu
Qiu, Shi
Cao, Dehong
Jin, Kun
Li, Jin
Chen, Bo
Huang, Yin
Bao, Yige
Liu, Liangren
Wei, Qiang
author_sort Wang, Xingyuan
collection PubMed
description OBJECTIVE: To study the effect of cryptorchidism on clinical stage (CS) of testicular seminoma (TS). PATIENTS AND METHODS: In the Surveillance Epidemiology and End Results (SEER) database (2006‐2016), people with TS were enrolled in our research. Multivariable logistic regression models were constructed to compare the impact of cryptorchidism on CS. RESULTS: This research was based on the registry information of 12,991 TS patients. All patients with a median age of 36 (13–107) years were pathologically diagnosed with orchiectomy or needle biopsy specimens. Patients with CS I, II, and III TS accounted for 70.68% (n = 9182), 8.30% (n = 1078), and 5.75% (n = 747) of all patients, respectively; still there were 15.27% (n = 1984) of patients whose CS could not be identified or was not available. Among all included patients, 43.45% (n = 5644) of them had normal testis, 2.93% (n = 272) had cryptorchidism, and the primary site of 54.46% (n = 7075) of patients’ testis was unavailable. According to our study, patients with cryptorchidism were more likely to suffer advanced CS [OR=1.14, 95% CI (1.01–1.28), p=0.0407]. Furthermore, this effect became more remarkable after adjusting for other factors including age, region, marital status, race, year of diagnosis and laterality [OR=1.23, 95% CI (1.13–1.32), p<0.0001]. CONCLUSION: According to this study, TS patients with cryptorchidism would be at a higher risk of suffering advanced cancer than patients with normal testis. It demonstrates that surgical correction for cryptorchidism should be timely, and specific management should be conducted on this kind of TS patients.
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spelling pubmed-73207492020-06-29 Evaluating the Effect of Cryptorchidism on Clinical Stage of Testicular Seminoma Wang, Xingyuan Chen, Zeyu Qiu, Shi Cao, Dehong Jin, Kun Li, Jin Chen, Bo Huang, Yin Bao, Yige Liu, Liangren Wei, Qiang Cancer Manag Res Original Research OBJECTIVE: To study the effect of cryptorchidism on clinical stage (CS) of testicular seminoma (TS). PATIENTS AND METHODS: In the Surveillance Epidemiology and End Results (SEER) database (2006‐2016), people with TS were enrolled in our research. Multivariable logistic regression models were constructed to compare the impact of cryptorchidism on CS. RESULTS: This research was based on the registry information of 12,991 TS patients. All patients with a median age of 36 (13–107) years were pathologically diagnosed with orchiectomy or needle biopsy specimens. Patients with CS I, II, and III TS accounted for 70.68% (n = 9182), 8.30% (n = 1078), and 5.75% (n = 747) of all patients, respectively; still there were 15.27% (n = 1984) of patients whose CS could not be identified or was not available. Among all included patients, 43.45% (n = 5644) of them had normal testis, 2.93% (n = 272) had cryptorchidism, and the primary site of 54.46% (n = 7075) of patients’ testis was unavailable. According to our study, patients with cryptorchidism were more likely to suffer advanced CS [OR=1.14, 95% CI (1.01–1.28), p=0.0407]. Furthermore, this effect became more remarkable after adjusting for other factors including age, region, marital status, race, year of diagnosis and laterality [OR=1.23, 95% CI (1.13–1.32), p<0.0001]. CONCLUSION: According to this study, TS patients with cryptorchidism would be at a higher risk of suffering advanced cancer than patients with normal testis. It demonstrates that surgical correction for cryptorchidism should be timely, and specific management should be conducted on this kind of TS patients. Dove 2020-06-23 /pmc/articles/PMC7320749/ /pubmed/32606976 http://dx.doi.org/10.2147/CMAR.S236618 Text en © 2020 Wang et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Wang, Xingyuan
Chen, Zeyu
Qiu, Shi
Cao, Dehong
Jin, Kun
Li, Jin
Chen, Bo
Huang, Yin
Bao, Yige
Liu, Liangren
Wei, Qiang
Evaluating the Effect of Cryptorchidism on Clinical Stage of Testicular Seminoma
title Evaluating the Effect of Cryptorchidism on Clinical Stage of Testicular Seminoma
title_full Evaluating the Effect of Cryptorchidism on Clinical Stage of Testicular Seminoma
title_fullStr Evaluating the Effect of Cryptorchidism on Clinical Stage of Testicular Seminoma
title_full_unstemmed Evaluating the Effect of Cryptorchidism on Clinical Stage of Testicular Seminoma
title_short Evaluating the Effect of Cryptorchidism on Clinical Stage of Testicular Seminoma
title_sort evaluating the effect of cryptorchidism on clinical stage of testicular seminoma
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320749/
https://www.ncbi.nlm.nih.gov/pubmed/32606976
http://dx.doi.org/10.2147/CMAR.S236618
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