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Viral nanoparticles for drug delivery, imaging, immunotherapy, and theranostic applications

Viral nanoparticles (VNPs) encompass a diverse array of naturally occurring nanomaterials derived from plant viruses, bacteriophages, and mammalian viruses. The application and development of VNPs and their genome-free versions, the virus-like particles (VLPs), for nanomedicine is a rapidly growing....

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Detalles Bibliográficos
Autores principales: Chung, Young Hun, Cai, Hui, Steinmetz, Nicole F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320870/
https://www.ncbi.nlm.nih.gov/pubmed/32603813
http://dx.doi.org/10.1016/j.addr.2020.06.024
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author Chung, Young Hun
Cai, Hui
Steinmetz, Nicole F.
author_facet Chung, Young Hun
Cai, Hui
Steinmetz, Nicole F.
author_sort Chung, Young Hun
collection PubMed
description Viral nanoparticles (VNPs) encompass a diverse array of naturally occurring nanomaterials derived from plant viruses, bacteriophages, and mammalian viruses. The application and development of VNPs and their genome-free versions, the virus-like particles (VLPs), for nanomedicine is a rapidly growing. VLPs can encapsulate a wide range of active ingredients as well as be genetically or chemically conjugated to targeting ligands to achieve tissue specificity. VLPs are manufactured through scalable fermentation or molecular farming, and the materials are biocompatible and biodegradable. These properties have led to a wide range of applications, including cancer therapies, immunotherapies, vaccines, antimicrobial therapies, cardiovascular therapies, gene therapies, as well as imaging and theranostics. The use of VLPs as drug delivery agents is evolving, and sufficient research must continuously be undertaken to translate these therapies to the clinic. This review highlights some of the novel research efforts currently underway in the VNP drug delivery field in achieving this greater goal.
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spelling pubmed-73208702020-06-29 Viral nanoparticles for drug delivery, imaging, immunotherapy, and theranostic applications Chung, Young Hun Cai, Hui Steinmetz, Nicole F. Adv Drug Deliv Rev Article Viral nanoparticles (VNPs) encompass a diverse array of naturally occurring nanomaterials derived from plant viruses, bacteriophages, and mammalian viruses. The application and development of VNPs and their genome-free versions, the virus-like particles (VLPs), for nanomedicine is a rapidly growing. VLPs can encapsulate a wide range of active ingredients as well as be genetically or chemically conjugated to targeting ligands to achieve tissue specificity. VLPs are manufactured through scalable fermentation or molecular farming, and the materials are biocompatible and biodegradable. These properties have led to a wide range of applications, including cancer therapies, immunotherapies, vaccines, antimicrobial therapies, cardiovascular therapies, gene therapies, as well as imaging and theranostics. The use of VLPs as drug delivery agents is evolving, and sufficient research must continuously be undertaken to translate these therapies to the clinic. This review highlights some of the novel research efforts currently underway in the VNP drug delivery field in achieving this greater goal. Elsevier B.V. 2020 2020-06-27 /pmc/articles/PMC7320870/ /pubmed/32603813 http://dx.doi.org/10.1016/j.addr.2020.06.024 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Chung, Young Hun
Cai, Hui
Steinmetz, Nicole F.
Viral nanoparticles for drug delivery, imaging, immunotherapy, and theranostic applications
title Viral nanoparticles for drug delivery, imaging, immunotherapy, and theranostic applications
title_full Viral nanoparticles for drug delivery, imaging, immunotherapy, and theranostic applications
title_fullStr Viral nanoparticles for drug delivery, imaging, immunotherapy, and theranostic applications
title_full_unstemmed Viral nanoparticles for drug delivery, imaging, immunotherapy, and theranostic applications
title_short Viral nanoparticles for drug delivery, imaging, immunotherapy, and theranostic applications
title_sort viral nanoparticles for drug delivery, imaging, immunotherapy, and theranostic applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320870/
https://www.ncbi.nlm.nih.gov/pubmed/32603813
http://dx.doi.org/10.1016/j.addr.2020.06.024
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