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Pathology-confirmed versus non pathology-confirmed cancer diagnoses: incidence, participant characteristics, and survival

Cancer diagnoses which are not confirmed by pathology are often under-registered in cancer registries compared to pathology-confirmed diagnoses. It is unknown how many patients have a non pathology-confirmed cancer diagnosis, and whether their characteristics and survival differ from patients with a...

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Autores principales: van der Willik, Kimberly D., Rojas-Saunero, Liliana P., Labrecque, Jeremy A., Ikram, M. Arfan, Schagen, Sanne B., Stricker, Bruno H., Ruiter, Rikje
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320936/
https://www.ncbi.nlm.nih.gov/pubmed/31863226
http://dx.doi.org/10.1007/s10654-019-00592-5
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author van der Willik, Kimberly D.
Rojas-Saunero, Liliana P.
Labrecque, Jeremy A.
Ikram, M. Arfan
Schagen, Sanne B.
Stricker, Bruno H.
Ruiter, Rikje
author_facet van der Willik, Kimberly D.
Rojas-Saunero, Liliana P.
Labrecque, Jeremy A.
Ikram, M. Arfan
Schagen, Sanne B.
Stricker, Bruno H.
Ruiter, Rikje
author_sort van der Willik, Kimberly D.
collection PubMed
description Cancer diagnoses which are not confirmed by pathology are often under-registered in cancer registries compared to pathology-confirmed diagnoses. It is unknown how many patients have a non pathology-confirmed cancer diagnosis, and whether their characteristics and survival differ from patients with a pathology-confirmed diagnosis. Participants from the prospective population-based Rotterdam Study were followed between 1989 and 2013 for the diagnosis of cancer. Cancer diagnoses were classified into pathology-confirmed versus non pathology-confirmed (i.e., based on imaging or tumour markers). We compared participant characteristics and the distribution of cancers at different sites. Furthermore, we investigated differences in overall survival using survival curves adjusted for age and sex. During a median (interquartile range) follow-up of 10.7 (6.3–15.9) years, 2698 out of 14,024 participants were diagnosed with cancer, of which 316 diagnoses (11.7%) were non pathology-confirmed. Participants with non pathology-confirmed diagnoses were older, more often women, and had a lower education. Most frequently non pathology-confirmed cancer sites included central nervous system (66.7%), hepato-pancreato-biliary (44.5%), and unknown primary origin (31.2%). Survival of participants with non pathology-confirmed diagnoses after 1 year was lower compared to survival of participants with pathology-confirmed diagnoses (32.6% vs. 63.4%; risk difference of 30.8% [95% CI 25.2%; 36.2%]). Pathological confirmation of cancer is related to participant characteristics and cancer site. Furthermore, participants with non pathology-confirmed diagnoses have worse survival than participants with pathology-confirmed diagnoses. Missing data on non pathology-confirmed diagnoses may result in underestimation of cancer incidence and in an overestimation of survival in cancer registries, and may introduce bias in aetiological research. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10654-019-00592-5) contains supplementary material, which is available to authorized users.
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spelling pubmed-73209362020-07-01 Pathology-confirmed versus non pathology-confirmed cancer diagnoses: incidence, participant characteristics, and survival van der Willik, Kimberly D. Rojas-Saunero, Liliana P. Labrecque, Jeremy A. Ikram, M. Arfan Schagen, Sanne B. Stricker, Bruno H. Ruiter, Rikje Eur J Epidemiol Cancer Cancer diagnoses which are not confirmed by pathology are often under-registered in cancer registries compared to pathology-confirmed diagnoses. It is unknown how many patients have a non pathology-confirmed cancer diagnosis, and whether their characteristics and survival differ from patients with a pathology-confirmed diagnosis. Participants from the prospective population-based Rotterdam Study were followed between 1989 and 2013 for the diagnosis of cancer. Cancer diagnoses were classified into pathology-confirmed versus non pathology-confirmed (i.e., based on imaging or tumour markers). We compared participant characteristics and the distribution of cancers at different sites. Furthermore, we investigated differences in overall survival using survival curves adjusted for age and sex. During a median (interquartile range) follow-up of 10.7 (6.3–15.9) years, 2698 out of 14,024 participants were diagnosed with cancer, of which 316 diagnoses (11.7%) were non pathology-confirmed. Participants with non pathology-confirmed diagnoses were older, more often women, and had a lower education. Most frequently non pathology-confirmed cancer sites included central nervous system (66.7%), hepato-pancreato-biliary (44.5%), and unknown primary origin (31.2%). Survival of participants with non pathology-confirmed diagnoses after 1 year was lower compared to survival of participants with pathology-confirmed diagnoses (32.6% vs. 63.4%; risk difference of 30.8% [95% CI 25.2%; 36.2%]). Pathological confirmation of cancer is related to participant characteristics and cancer site. Furthermore, participants with non pathology-confirmed diagnoses have worse survival than participants with pathology-confirmed diagnoses. Missing data on non pathology-confirmed diagnoses may result in underestimation of cancer incidence and in an overestimation of survival in cancer registries, and may introduce bias in aetiological research. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10654-019-00592-5) contains supplementary material, which is available to authorized users. Springer Netherlands 2019-12-20 2020 /pmc/articles/PMC7320936/ /pubmed/31863226 http://dx.doi.org/10.1007/s10654-019-00592-5 Text en © The Author(s) 2019 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Cancer
van der Willik, Kimberly D.
Rojas-Saunero, Liliana P.
Labrecque, Jeremy A.
Ikram, M. Arfan
Schagen, Sanne B.
Stricker, Bruno H.
Ruiter, Rikje
Pathology-confirmed versus non pathology-confirmed cancer diagnoses: incidence, participant characteristics, and survival
title Pathology-confirmed versus non pathology-confirmed cancer diagnoses: incidence, participant characteristics, and survival
title_full Pathology-confirmed versus non pathology-confirmed cancer diagnoses: incidence, participant characteristics, and survival
title_fullStr Pathology-confirmed versus non pathology-confirmed cancer diagnoses: incidence, participant characteristics, and survival
title_full_unstemmed Pathology-confirmed versus non pathology-confirmed cancer diagnoses: incidence, participant characteristics, and survival
title_short Pathology-confirmed versus non pathology-confirmed cancer diagnoses: incidence, participant characteristics, and survival
title_sort pathology-confirmed versus non pathology-confirmed cancer diagnoses: incidence, participant characteristics, and survival
topic Cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320936/
https://www.ncbi.nlm.nih.gov/pubmed/31863226
http://dx.doi.org/10.1007/s10654-019-00592-5
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