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Comparison of apolipoprotein-A1 levels between paroxysmal atrial fibrillation patients and healthy subjects
Introduction: Studies found that the inflammation plays a key role in the pathogenesis of paroxysmal atrial fibrillation (PAF). It is well-known that apolipoprotein-A1 (Apo-A1) demonstrates antiinflammatory and anti-oxidant properties in a healthy physiological system. In the present study, we aimed...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tabriz University of Medical Sciences
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320999/ https://www.ncbi.nlm.nih.gov/pubmed/32626555 http://dx.doi.org/10.34172/jcvtr.2020.23 |
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author | Çınar, Tufan Tanık, Veysel Ozan Gürkan, Kadir |
author_facet | Çınar, Tufan Tanık, Veysel Ozan Gürkan, Kadir |
author_sort | Çınar, Tufan |
collection | PubMed |
description | Introduction: Studies found that the inflammation plays a key role in the pathogenesis of paroxysmal atrial fibrillation (PAF). It is well-known that apolipoprotein-A1 (Apo-A1) demonstrates antiinflammatory and anti-oxidant properties in a healthy physiological system. In the present study, we aimed to determine whether there is any difference of Apo-A1 levels in patients with PAF and healthy subjects. Methods: In this prospective cohort study, we enrolled a total of 35 PAF patients and 34 comparable healthy participants. Apo-A1 levels were measured from each subject using an immunophelometric method. All enrolled subjects were followed-up for one year during the study period. Results: Serum high-sensitivity C-reactive protein (hs-CRP) levels were statistically higher in PAF patients compared to healthy subjects (1.54±1.99 vs. 1.06±2.01, P = 0.016, respectively). Of note, patients with PAF had lower Apo-A1 levels (1.84±0.74 vs. 2.55±0.44, P = 0.001, respectively). There was no statistical difference between the groups in terms of apolipoprotein-B levels (1.08±0.36 vs. 0.99±0.38, P = 0.339, respectively). We did not find any correlation between Apo-A1 levels and PAF attacks in the study. Conclusion: The main finding of this study was that Apo-A1 levels were significantly lower in PAF patients compared to healthy participants. Based on our results, we considered that Apo-A1 may have a key role in the pathogenesis of PAF. |
format | Online Article Text |
id | pubmed-7320999 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Tabriz University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-73209992020-07-02 Comparison of apolipoprotein-A1 levels between paroxysmal atrial fibrillation patients and healthy subjects Çınar, Tufan Tanık, Veysel Ozan Gürkan, Kadir J Cardiovasc Thorac Res Short Communication Introduction: Studies found that the inflammation plays a key role in the pathogenesis of paroxysmal atrial fibrillation (PAF). It is well-known that apolipoprotein-A1 (Apo-A1) demonstrates antiinflammatory and anti-oxidant properties in a healthy physiological system. In the present study, we aimed to determine whether there is any difference of Apo-A1 levels in patients with PAF and healthy subjects. Methods: In this prospective cohort study, we enrolled a total of 35 PAF patients and 34 comparable healthy participants. Apo-A1 levels were measured from each subject using an immunophelometric method. All enrolled subjects were followed-up for one year during the study period. Results: Serum high-sensitivity C-reactive protein (hs-CRP) levels were statistically higher in PAF patients compared to healthy subjects (1.54±1.99 vs. 1.06±2.01, P = 0.016, respectively). Of note, patients with PAF had lower Apo-A1 levels (1.84±0.74 vs. 2.55±0.44, P = 0.001, respectively). There was no statistical difference between the groups in terms of apolipoprotein-B levels (1.08±0.36 vs. 0.99±0.38, P = 0.339, respectively). We did not find any correlation between Apo-A1 levels and PAF attacks in the study. Conclusion: The main finding of this study was that Apo-A1 levels were significantly lower in PAF patients compared to healthy participants. Based on our results, we considered that Apo-A1 may have a key role in the pathogenesis of PAF. Tabriz University of Medical Sciences 2020 2020-05-17 /pmc/articles/PMC7320999/ /pubmed/32626555 http://dx.doi.org/10.34172/jcvtr.2020.23 Text en © 2020 The Author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Çınar, Tufan Tanık, Veysel Ozan Gürkan, Kadir Comparison of apolipoprotein-A1 levels between paroxysmal atrial fibrillation patients and healthy subjects |
title | Comparison of apolipoprotein-A1 levels between paroxysmal atrial fibrillation patients and healthy subjects |
title_full | Comparison of apolipoprotein-A1 levels between paroxysmal atrial fibrillation patients and healthy subjects |
title_fullStr | Comparison of apolipoprotein-A1 levels between paroxysmal atrial fibrillation patients and healthy subjects |
title_full_unstemmed | Comparison of apolipoprotein-A1 levels between paroxysmal atrial fibrillation patients and healthy subjects |
title_short | Comparison of apolipoprotein-A1 levels between paroxysmal atrial fibrillation patients and healthy subjects |
title_sort | comparison of apolipoprotein-a1 levels between paroxysmal atrial fibrillation patients and healthy subjects |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320999/ https://www.ncbi.nlm.nih.gov/pubmed/32626555 http://dx.doi.org/10.34172/jcvtr.2020.23 |
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