Cytokine Storms: Understanding COVID-19

The elevated circulating levels of cytokines associated with a variety of infectious and immune-mediated conditions are frequently termed a cytokine storm. Here, we explain the protective functions of cytokines in “ideal” responses; the multi-factorial origins that can drive these responses to becom...

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Detalles Bibliográficos
Autores principales: Mangalmurti, Nilam, Hunter, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321048/
https://www.ncbi.nlm.nih.gov/pubmed/32610079
http://dx.doi.org/10.1016/j.immuni.2020.06.017
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author Mangalmurti, Nilam
Hunter, Christopher A.
author_facet Mangalmurti, Nilam
Hunter, Christopher A.
author_sort Mangalmurti, Nilam
collection PubMed
description The elevated circulating levels of cytokines associated with a variety of infectious and immune-mediated conditions are frequently termed a cytokine storm. Here, we explain the protective functions of cytokines in “ideal” responses; the multi-factorial origins that can drive these responses to become pathological; and how this ultimately leads to vascular damage, immunopathology, and worsening clinical outcomes.
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spelling pubmed-73210482020-06-29 Cytokine Storms: Understanding COVID-19 Mangalmurti, Nilam Hunter, Christopher A. Immunity Article The elevated circulating levels of cytokines associated with a variety of infectious and immune-mediated conditions are frequently termed a cytokine storm. Here, we explain the protective functions of cytokines in “ideal” responses; the multi-factorial origins that can drive these responses to become pathological; and how this ultimately leads to vascular damage, immunopathology, and worsening clinical outcomes. Elsevier Inc. 2020-07-14 2020-06-28 /pmc/articles/PMC7321048/ /pubmed/32610079 http://dx.doi.org/10.1016/j.immuni.2020.06.017 Text en © 2020 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Mangalmurti, Nilam
Hunter, Christopher A.
Cytokine Storms: Understanding COVID-19
title Cytokine Storms: Understanding COVID-19
title_full Cytokine Storms: Understanding COVID-19
title_fullStr Cytokine Storms: Understanding COVID-19
title_full_unstemmed Cytokine Storms: Understanding COVID-19
title_short Cytokine Storms: Understanding COVID-19
title_sort cytokine storms: understanding covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321048/
https://www.ncbi.nlm.nih.gov/pubmed/32610079
http://dx.doi.org/10.1016/j.immuni.2020.06.017
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