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Cooperative Binding and Stepwise Encapsulation of Drug Molecules by Sulfonylcalixarene-Based Metal-Organic Supercontainers

The cooperative binding behavior of a face-directed octahedral metal-organic supercontainer featuring one endo cavity and six exo cavities was thoroughly examined in chloroform solution through ultraviolet-visible (UV-Vis) titration technique using two representative drug molecules as the guests. Th...

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Autores principales: Sheng, Tian-Pu, Fan, Xin-Xia, Zheng, Guo-Zong, Dai, Feng-Rong, Chen, Zhong-Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321066/
https://www.ncbi.nlm.nih.gov/pubmed/32521606
http://dx.doi.org/10.3390/molecules25112656
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author Sheng, Tian-Pu
Fan, Xin-Xia
Zheng, Guo-Zong
Dai, Feng-Rong
Chen, Zhong-Ning
author_facet Sheng, Tian-Pu
Fan, Xin-Xia
Zheng, Guo-Zong
Dai, Feng-Rong
Chen, Zhong-Ning
author_sort Sheng, Tian-Pu
collection PubMed
description The cooperative binding behavior of a face-directed octahedral metal-organic supercontainer featuring one endo cavity and six exo cavities was thoroughly examined in chloroform solution through ultraviolet-visible (UV-Vis) titration technique using two representative drug molecules as the guests. The titration curves and their nonlinear fit to Hill equation strongly suggest the efficient encapsulation of the guest molecules by the synthetic host, which exhibit interesting cooperative and stepwise binding behavior. Based on the control experiments using tetranuclear complex as a reference, it is clear that two equivalents of the guest molecules are initially encapsulated inside the endo cavity, followed by the trapping of six additional equivalents of the drug molecules through six exo cavities (1 eq. per exo cavity), and the remaining guests are entrapped by the external pockets. The results provide an in-depth understanding of the cooperative binding behavior of metal-organic supercontainers, which opens up new opportunities for designing synthetic receptors for truly biomimetic functional applications.
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spelling pubmed-73210662020-07-06 Cooperative Binding and Stepwise Encapsulation of Drug Molecules by Sulfonylcalixarene-Based Metal-Organic Supercontainers Sheng, Tian-Pu Fan, Xin-Xia Zheng, Guo-Zong Dai, Feng-Rong Chen, Zhong-Ning Molecules Article The cooperative binding behavior of a face-directed octahedral metal-organic supercontainer featuring one endo cavity and six exo cavities was thoroughly examined in chloroform solution through ultraviolet-visible (UV-Vis) titration technique using two representative drug molecules as the guests. The titration curves and their nonlinear fit to Hill equation strongly suggest the efficient encapsulation of the guest molecules by the synthetic host, which exhibit interesting cooperative and stepwise binding behavior. Based on the control experiments using tetranuclear complex as a reference, it is clear that two equivalents of the guest molecules are initially encapsulated inside the endo cavity, followed by the trapping of six additional equivalents of the drug molecules through six exo cavities (1 eq. per exo cavity), and the remaining guests are entrapped by the external pockets. The results provide an in-depth understanding of the cooperative binding behavior of metal-organic supercontainers, which opens up new opportunities for designing synthetic receptors for truly biomimetic functional applications. MDPI 2020-06-08 /pmc/articles/PMC7321066/ /pubmed/32521606 http://dx.doi.org/10.3390/molecules25112656 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sheng, Tian-Pu
Fan, Xin-Xia
Zheng, Guo-Zong
Dai, Feng-Rong
Chen, Zhong-Ning
Cooperative Binding and Stepwise Encapsulation of Drug Molecules by Sulfonylcalixarene-Based Metal-Organic Supercontainers
title Cooperative Binding and Stepwise Encapsulation of Drug Molecules by Sulfonylcalixarene-Based Metal-Organic Supercontainers
title_full Cooperative Binding and Stepwise Encapsulation of Drug Molecules by Sulfonylcalixarene-Based Metal-Organic Supercontainers
title_fullStr Cooperative Binding and Stepwise Encapsulation of Drug Molecules by Sulfonylcalixarene-Based Metal-Organic Supercontainers
title_full_unstemmed Cooperative Binding and Stepwise Encapsulation of Drug Molecules by Sulfonylcalixarene-Based Metal-Organic Supercontainers
title_short Cooperative Binding and Stepwise Encapsulation of Drug Molecules by Sulfonylcalixarene-Based Metal-Organic Supercontainers
title_sort cooperative binding and stepwise encapsulation of drug molecules by sulfonylcalixarene-based metal-organic supercontainers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321066/
https://www.ncbi.nlm.nih.gov/pubmed/32521606
http://dx.doi.org/10.3390/molecules25112656
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