Corynanthean-Epicatechin Flavoalkaloids from Corynanthe pachyceras

Epicatechocorynantheines A and B, and epicatechocorynantheidine were isolated from the stem bark of Corynanthe pachyceras. These molecules were pinpointed, and their isolation streamlined, by a molecular networking strategy. The structural elucidation was unambiguously accomplished from HRMS and 1D/...

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Detalles Bibliográficos
Autores principales: Kouamé, Tapé, Okpekon, Aboua Timothée, Bony, Nicaise F., N’Tamon, Amon Diane, Gallard, Jean-François, Rharrabti, Somia, Leblanc, Karine, Mouray, Elisabeth, Grellier, Philippe, Champy, Pierre, Beniddir, Mehdi A., Le Pogam, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321195/
https://www.ncbi.nlm.nih.gov/pubmed/32517373
http://dx.doi.org/10.3390/molecules25112654
Descripción
Sumario:Epicatechocorynantheines A and B, and epicatechocorynantheidine were isolated from the stem bark of Corynanthe pachyceras. These molecules were pinpointed, and their isolation streamlined, by a molecular networking strategy. The structural elucidation was unambiguously accomplished from HRMS and 1D/2D NMR data. These compounds represent the first examples of corynanthean-type alkaloids tethered with a flavonoid. Epicatechocorynantheidine notably instigated two connections between the monoterpene indole alkaloid and the flavonoid, yielding an unprecedented octacyclic appendage. These flavoalkaloids exerted moderate antiplasmodial activities.

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