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Corynanthean-Epicatechin Flavoalkaloids from Corynanthe pachyceras
Epicatechocorynantheines A and B, and epicatechocorynantheidine were isolated from the stem bark of Corynanthe pachyceras. These molecules were pinpointed, and their isolation streamlined, by a molecular networking strategy. The structural elucidation was unambiguously accomplished from HRMS and 1D/...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321195/ https://www.ncbi.nlm.nih.gov/pubmed/32517373 http://dx.doi.org/10.3390/molecules25112654 |
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| author | Kouamé, Tapé Okpekon, Aboua Timothée Bony, Nicaise F. N’Tamon, Amon Diane Gallard, Jean-François Rharrabti, Somia Leblanc, Karine Mouray, Elisabeth Grellier, Philippe Champy, Pierre Beniddir, Mehdi A. Le Pogam, Pierre |
| author_facet | Kouamé, Tapé Okpekon, Aboua Timothée Bony, Nicaise F. N’Tamon, Amon Diane Gallard, Jean-François Rharrabti, Somia Leblanc, Karine Mouray, Elisabeth Grellier, Philippe Champy, Pierre Beniddir, Mehdi A. Le Pogam, Pierre |
| author_sort | Kouamé, Tapé |
| collection | PubMed |
| description | Epicatechocorynantheines A and B, and epicatechocorynantheidine were isolated from the stem bark of Corynanthe pachyceras. These molecules were pinpointed, and their isolation streamlined, by a molecular networking strategy. The structural elucidation was unambiguously accomplished from HRMS and 1D/2D NMR data. These compounds represent the first examples of corynanthean-type alkaloids tethered with a flavonoid. Epicatechocorynantheidine notably instigated two connections between the monoterpene indole alkaloid and the flavonoid, yielding an unprecedented octacyclic appendage. These flavoalkaloids exerted moderate antiplasmodial activities. |
| format | Online Article Text |
| id | pubmed-7321195 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-73211952020-07-06 Corynanthean-Epicatechin Flavoalkaloids from Corynanthe pachyceras Kouamé, Tapé Okpekon, Aboua Timothée Bony, Nicaise F. N’Tamon, Amon Diane Gallard, Jean-François Rharrabti, Somia Leblanc, Karine Mouray, Elisabeth Grellier, Philippe Champy, Pierre Beniddir, Mehdi A. Le Pogam, Pierre Molecules Article Epicatechocorynantheines A and B, and epicatechocorynantheidine were isolated from the stem bark of Corynanthe pachyceras. These molecules were pinpointed, and their isolation streamlined, by a molecular networking strategy. The structural elucidation was unambiguously accomplished from HRMS and 1D/2D NMR data. These compounds represent the first examples of corynanthean-type alkaloids tethered with a flavonoid. Epicatechocorynantheidine notably instigated two connections between the monoterpene indole alkaloid and the flavonoid, yielding an unprecedented octacyclic appendage. These flavoalkaloids exerted moderate antiplasmodial activities. MDPI 2020-06-07 /pmc/articles/PMC7321195/ /pubmed/32517373 http://dx.doi.org/10.3390/molecules25112654 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Kouamé, Tapé Okpekon, Aboua Timothée Bony, Nicaise F. N’Tamon, Amon Diane Gallard, Jean-François Rharrabti, Somia Leblanc, Karine Mouray, Elisabeth Grellier, Philippe Champy, Pierre Beniddir, Mehdi A. Le Pogam, Pierre Corynanthean-Epicatechin Flavoalkaloids from Corynanthe pachyceras |
| title | Corynanthean-Epicatechin Flavoalkaloids from Corynanthe pachyceras |
| title_full | Corynanthean-Epicatechin Flavoalkaloids from Corynanthe pachyceras |
| title_fullStr | Corynanthean-Epicatechin Flavoalkaloids from Corynanthe pachyceras |
| title_full_unstemmed | Corynanthean-Epicatechin Flavoalkaloids from Corynanthe pachyceras |
| title_short | Corynanthean-Epicatechin Flavoalkaloids from Corynanthe pachyceras |
| title_sort | corynanthean-epicatechin flavoalkaloids from corynanthe pachyceras |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321195/ https://www.ncbi.nlm.nih.gov/pubmed/32517373 http://dx.doi.org/10.3390/molecules25112654 |
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