Verification of the Necessity of the Tolyl Group of PF-543 for Sphingosine Kinase 1 Inhibitory Activity

PF-543, the most potent sphingosine kinase (SK) inhibitor, does not demonstrate effective anticancer activity in some cancer cells, unlike other known SK1 inhibitors. PF-543 has a non-lipid structure with a unique toluene backbone; however, the importance of this structure remains unclear. Therefore...

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Detalles Bibliográficos
Autores principales: Kim, Su Bin, Lee, Taeho, Moon, Hong Seop, Ki, Sung Hwan, Oh, Yoon Sin, Lee, Joo-Youn, Kim, Sang-Bum, Park, Jeong-Eun, Kwon, Yongseok, Kim, Sanghee, Baek, Dong Jae, Park, Eun-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321251/
https://www.ncbi.nlm.nih.gov/pubmed/32471162
http://dx.doi.org/10.3390/molecules25112484

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