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New Morphiceptin Peptidomimetic Incorporating (1S,2R,3S,4S,5R)-2-Amino-3,4,5-trihydroxycyclopen-tane-1-carboxylic acid: Synthesis and Structural Study

We present the synthesis and structural study of a new peptidomimetic of morphiceptin, which can formally be considered as the result of the replacement of the central proline residue of this natural analgesic drug with a subunit of (1S,2R,3S,4S,5R)-2-amino-3,4,5-trihydroxycyclopentane-1-carboxylic...

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Detalles Bibliográficos
Autores principales: Soengas, Raquel, Lorca, Marcos, Pampín, Begoña, Sánchez-Pedregal, Víctor M., Estévez, Ramón J., Estévez, Juan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321350/
https://www.ncbi.nlm.nih.gov/pubmed/32492956
http://dx.doi.org/10.3390/molecules25112574