An Efficient Greener Approach for N-acylation of Amines in Water Using Benzotriazole Chemistry

A straightforward, mild and cost-efficient synthesis of various arylamides in water was accomplished using versatile benzotriazole chemistry. Acylation of various amines was achieved in water at room temperature as well as under microwave irradiation. The developed protocol unfolds the synthesis of...

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Autores principales: Ibrahim, Tarek S., Seliem, Israa A., Panda, Siva S., Al-Mahmoudy, Amany M. M., Abdel-Samii, Zakaria K. M., Alhakamy, Nabil A., Asfour, Hani Z., Elagawany, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321353/
https://www.ncbi.nlm.nih.gov/pubmed/32481504
http://dx.doi.org/10.3390/molecules25112501
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author Ibrahim, Tarek S.
Seliem, Israa A.
Panda, Siva S.
Al-Mahmoudy, Amany M. M.
Abdel-Samii, Zakaria K. M.
Alhakamy, Nabil A.
Asfour, Hani Z.
Elagawany, Mohamed
author_facet Ibrahim, Tarek S.
Seliem, Israa A.
Panda, Siva S.
Al-Mahmoudy, Amany M. M.
Abdel-Samii, Zakaria K. M.
Alhakamy, Nabil A.
Asfour, Hani Z.
Elagawany, Mohamed
author_sort Ibrahim, Tarek S.
collection PubMed
description A straightforward, mild and cost-efficient synthesis of various arylamides in water was accomplished using versatile benzotriazole chemistry. Acylation of various amines was achieved in water at room temperature as well as under microwave irradiation. The developed protocol unfolds the synthesis of amino acid aryl amides, drug conjugates and benzimidazoles. The environmentally friendly synthesis, short reaction time, simple workup, high yields, mild conditions and free of racemization are the key advantages of this protocol.
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spelling pubmed-73213532020-06-29 An Efficient Greener Approach for N-acylation of Amines in Water Using Benzotriazole Chemistry Ibrahim, Tarek S. Seliem, Israa A. Panda, Siva S. Al-Mahmoudy, Amany M. M. Abdel-Samii, Zakaria K. M. Alhakamy, Nabil A. Asfour, Hani Z. Elagawany, Mohamed Molecules Article A straightforward, mild and cost-efficient synthesis of various arylamides in water was accomplished using versatile benzotriazole chemistry. Acylation of various amines was achieved in water at room temperature as well as under microwave irradiation. The developed protocol unfolds the synthesis of amino acid aryl amides, drug conjugates and benzimidazoles. The environmentally friendly synthesis, short reaction time, simple workup, high yields, mild conditions and free of racemization are the key advantages of this protocol. MDPI 2020-05-28 /pmc/articles/PMC7321353/ /pubmed/32481504 http://dx.doi.org/10.3390/molecules25112501 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ibrahim, Tarek S.
Seliem, Israa A.
Panda, Siva S.
Al-Mahmoudy, Amany M. M.
Abdel-Samii, Zakaria K. M.
Alhakamy, Nabil A.
Asfour, Hani Z.
Elagawany, Mohamed
An Efficient Greener Approach for N-acylation of Amines in Water Using Benzotriazole Chemistry
title An Efficient Greener Approach for N-acylation of Amines in Water Using Benzotriazole Chemistry
title_full An Efficient Greener Approach for N-acylation of Amines in Water Using Benzotriazole Chemistry
title_fullStr An Efficient Greener Approach for N-acylation of Amines in Water Using Benzotriazole Chemistry
title_full_unstemmed An Efficient Greener Approach for N-acylation of Amines in Water Using Benzotriazole Chemistry
title_short An Efficient Greener Approach for N-acylation of Amines in Water Using Benzotriazole Chemistry
title_sort efficient greener approach for n-acylation of amines in water using benzotriazole chemistry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321353/
https://www.ncbi.nlm.nih.gov/pubmed/32481504
http://dx.doi.org/10.3390/molecules25112501
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