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Unsaturated Fatty Acid-Induced Conformational Transitions and Aggregation of the Repeat Domain of Tau

Background: The intrinsically disordered, amyloidogenic protein Tau associates with diverse classes of molecules, including proteins, nucleic acids, and lipids. Mounting evidence suggests that fatty acid molecules could play a role in the dysfunction of this protein, however, their interaction with...

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Detalles Bibliográficos
Autores principales: Barracchia, Carlo Giorgio, Tira, Roberto, Parolini, Francesca, Munari, Francesca, Bubacco, Luigi, Spyroulias, Georgios A., D’Onofrio, Mariapina, Assfalg, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321374/
https://www.ncbi.nlm.nih.gov/pubmed/32545360
http://dx.doi.org/10.3390/molecules25112716