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27-Hydroxycholesterol contributes to cognitive deficits in APP/PS1 transgenic mice through microbiota dysbiosis and intestinal barrier dysfunction

BACKGROUND: Research on the brain-gut-microbiota axis has led to accumulating interest in gut microbiota dysbiosis and intestinal barrier dysfunction in Alzheimer’s disease (AD). Our previous studies have demonstrated neurotoxic effects of 27-hydroxycholesterol (27-OHC) in in vitro and in vivo model...

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Detalles Bibliográficos
Autores principales:	Wang, Ying, An, Yu, Ma, Weiwei, Yu, Huiyan, Lu, Yanhui, Zhang, Xiaona, Wang, Yushan, Liu, Wen, Wang, Tao, Xiao, Rong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321549/ https://www.ncbi.nlm.nih.gov/pubmed/32593306 http://dx.doi.org/10.1186/s12974-020-01873-7

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