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Reposition of montelukast either alone or in combination with levocetirizine against SARS-CoV-2

It has been hypothesised that antiallergic medications (AAMs) like montelukast and levocetirizine both the two bitter chloro compounds could be repurposed either alone or combinedly as an antiviral against SARS-CoV-2, like chloroquine/hydroxychloroquine (CQ/HCQ), another two bitter chloro compounds....

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Autor principal: Bhattacharyya, Dipankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321662/
https://www.ncbi.nlm.nih.gov/pubmed/33254480
http://dx.doi.org/10.1016/j.mehy.2020.110046
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author Bhattacharyya, Dipankar
author_facet Bhattacharyya, Dipankar
author_sort Bhattacharyya, Dipankar
collection PubMed
description It has been hypothesised that antiallergic medications (AAMs) like montelukast and levocetirizine both the two bitter chloro compounds could be repurposed either alone or combinedly as an antiviral against SARS-CoV-2, like chloroquine/hydroxychloroquine (CQ/HCQ), another two bitter chloro compounds. Both AAMs and CQ/HCQ are bitter tasted chloro compounds. Depending on their these two similar physical properties and the safety and efficacy of AAMs by controlling over post viral episodes as comparing with viral inhibitory activities including SARS-CoV-2 by CQ/HCQ, a reposition of AAMs either alone/combinedly could be rationalised as an antiviral approach to nCoV.
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spelling pubmed-73216622020-06-29 Reposition of montelukast either alone or in combination with levocetirizine against SARS-CoV-2 Bhattacharyya, Dipankar Med Hypotheses Letter to Editors It has been hypothesised that antiallergic medications (AAMs) like montelukast and levocetirizine both the two bitter chloro compounds could be repurposed either alone or combinedly as an antiviral against SARS-CoV-2, like chloroquine/hydroxychloroquine (CQ/HCQ), another two bitter chloro compounds. Both AAMs and CQ/HCQ are bitter tasted chloro compounds. Depending on their these two similar physical properties and the safety and efficacy of AAMs by controlling over post viral episodes as comparing with viral inhibitory activities including SARS-CoV-2 by CQ/HCQ, a reposition of AAMs either alone/combinedly could be rationalised as an antiviral approach to nCoV. Elsevier Ltd. 2020-11 2020-06-28 /pmc/articles/PMC7321662/ /pubmed/33254480 http://dx.doi.org/10.1016/j.mehy.2020.110046 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Letter to Editors
Bhattacharyya, Dipankar
Reposition of montelukast either alone or in combination with levocetirizine against SARS-CoV-2
title Reposition of montelukast either alone or in combination with levocetirizine against SARS-CoV-2
title_full Reposition of montelukast either alone or in combination with levocetirizine against SARS-CoV-2
title_fullStr Reposition of montelukast either alone or in combination with levocetirizine against SARS-CoV-2
title_full_unstemmed Reposition of montelukast either alone or in combination with levocetirizine against SARS-CoV-2
title_short Reposition of montelukast either alone or in combination with levocetirizine against SARS-CoV-2
title_sort reposition of montelukast either alone or in combination with levocetirizine against sars-cov-2
topic Letter to Editors
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321662/
https://www.ncbi.nlm.nih.gov/pubmed/33254480
http://dx.doi.org/10.1016/j.mehy.2020.110046
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