Cargando…

Targeting IFN/STAT1 Pathway as a Promising Strategy to Overcome Radioresistance

The interferon (IFN)-mediated activation of the Janus kinase (JAK)-signal transducer and activator of transcription 1 (STAT1) signaling is crucial for cell sensitivity to ionizing radiation. Several preclinical studies have reported that the IFN/STAT1 pathway mediates radioresistance in the tumor mi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Shuya, Imani, Saber, Deng, Youcai, Pathak, Janak L, Wen, Qinglian, Chen, Yue, Wu, Jingbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321691/ https://www.ncbi.nlm.nih.gov/pubmed/32606809 http://dx.doi.org/10.2147/OTT.S256708

Ejemplares similares

Combination Therapy With Charged Particles and Molecular Targeting: A Promising Avenue to Overcome Radioresistance
por: Konings, Katrien, et al.
Publicado: (2020)

PLA1A expression as a diagnostic marker of BRAF-mutant metastasis in melanoma cancer
por: Yang, Gang, et al.
Publicado: (2021)

Hypoxic Radioresistance: Can ROS Be the Key to Overcome It?
por: Wang, Hui, et al.
Publicado: (2019)

Platinum nanoparticles: an exquisite tool to overcome radioresistance
por: Li, Sha, et al.
Publicado: (2017)

STAT3 Contributes to Radioresistance in Cancer
por: Wang, Xuehai, et al.
Publicado: (2020)

Targeting the STAT5A/IDO1 axis overcomes radioresistance and reverses the immunosuppressive tumor microenvironment in NSCLC
por: Yang, Yang, et al.
Publicado: (2022)

Inhibition of livin overcomes radioresistance in nasopharyngeal carcinoma cells
por: Ma, Fei, et al.
Publicado: (2020)

Natural Killer Cells: Friend or Foe in Metabolic Diseases?
por: Li, Yi, et al.
Publicado: (2021)

RIG-I immunotherapy overcomes radioresistance in p53-positive malignant melanoma
por: Lambing, Silke, et al.
Publicado: (2023)

STAT1-dependent expression of energy metabolic pathways links tumour growth and radioresistance to the Warburg effect
por: Pitroda, Sean P, et al.
Publicado: (2009)

Genome-wide copy number analysis of circulating tumor cells in breast cancer patients with liver metastasis
por: Zou, Linglin, et al.
Publicado: (2020)

Cancer stem cells and signaling pathways in radioresistance
por: Chang, Lei, et al.
Publicado: (2015)

FOXM1 and STAT3 interaction confers radioresistance in glioblastoma cells
por: Maachani, Uday B., et al.
Publicado: (2016)

Treatment of malignant pleural effusion in non-small cell lung cancer with VEGF-directed therapy
por: Xiang, Zhangqiang, et al.
Publicado: (2022)

IFN-λ3 Inhibits HIV Infection of Macrophages through the JAK-STAT Pathway
por: Liu, Man-Qing, et al.
Publicado: (2012)

Descriptive statistics of dataset from the meta-analysis and meta-regression analysis on prognostic significance of pre-treatment systemic hemato-immunological indices of cervical cancer patients
por: Han, Xingping, et al.
Publicado: (2021)

Targeting Cell Cycle Checkpoint Kinases to Overcome Intrinsic Radioresistance in Brain Tumor Cells
por: Vlatkovic, Tijana, et al.
Publicado: (2022)

Targeting Aurora B kinase with Tanshinone IIA suppresses tumor growth and overcomes radioresistance
por: Li, Ming, et al.
Publicado: (2021)

Heparin-binding growth factor (HDGF) drives radioresistance in breast cancer by activating the STAT3 signaling pathway
por: Qiu, Lingyun, et al.
Publicado: (2021)

Signaling pathway STAT1 is strongly activated by IFN-β in the pathogenesis of osteoporosis
por: Seeliger, Claudine, et al.
Publicado: (2015)

Targeting Epithelial-to-Mesenchymal Transition in Radioresistance: Crosslinked Mechanisms and Strategies
por: Qiao, Lili, et al.
Publicado: (2022)

Melatonin suppresses thyroid cancer growth and overcomes radioresistance via inhibition of p65 phosphorylation and induction of ROS
por: Zou, Zhen-Wei, et al.
Publicado: (2018)

Epigenetic Therapies as a Promising Strategy for Overcoming Chemoresistance in Epithelial Ovarian Cancer
por: Suh, Dong Hoon, et al.
Publicado: (2013)

Overcoming PARP inhibitor resistance in ovarian cancer: what are the most promising strategies?
por: Klotz, Daniel Martin, et al.
Publicado: (2020)

Targeting Lysosomes in Cancer as Promising Strategy to Overcome Chemoresistance—A Mini Review
por: Geisslinger, Franz, et al.
Publicado: (2020)

Multitargeting Compounds: A Promising Strategy to Overcome Multi-Drug Resistant Tuberculosis
por: Stelitano, Giovanni, et al.
Publicado: (2020)

Albumin-based nanoparticles: a promising strategy to overcome cancer drug resistance
por: Hassanin, Islam, et al.
Publicado: (2020)

Current Landscape of Therapeutic Resistance in Lung Cancer and Promising Strategies to Overcome Resistance
por: Ashrafi, Adnin, et al.
Publicado: (2022)

Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma
por: Bharadwaj, Uddalak, et al.
Publicado: (2016)

Dual blockage of STAT3 and ERK1/2 eliminates radioresistant GBM cells
por: Xie, Bowen, et al.
Publicado: (2019)

Advances in anti-viral immune defence: revealing the importance of the IFN JAK/STAT pathway
por: Raftery, Nicola, et al.
Publicado: (2017)

Endogenous Retrovirus Elements Are Co-Expressed with IFN Stimulation Genes in the JAK–STAT Pathway
por: Wang, Yanglan, et al.
Publicado: (2022)

LAG-3 expression in microglia regulated by IFN-γ/STAT1 pathway and metalloproteases
por: Morisaki, Yuta, et al.
Publicado: (2023)

Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists
por: Fleming, Stephen B.
Publicado: (2016)

An oncolytic virus as a promising candidate for the treatment of radioresistant oral squamous cell carcinoma
por: Gohara, Shunsuke, et al.
Publicado: (2022)

Novel insight into metabolic reprogrammming in cancer radioresistance: A promising therapeutic target in radiotherapy
por: Yu, Yilin, et al.
Publicado: (2023)

Overcoming radioresistance in WiDr cells with heavy ion irradiation and radiosensitization by 2-deoxyglucose with photon irradiation
por: Hasse, Felix Christian, et al.
Publicado: (2019)

Microbeam Radiotherapy—A Novel Therapeutic Approach to Overcome Radioresistance and Enhance Anti-Tumour Response in Melanoma
por: Trappetti, Verdiana, et al.
Publicado: (2021)

A Promising IFN-Deficient System to Manufacture IFN-Sensitive Influenza Vaccine Virus
por: Chen, Can, et al.
Publicado: (2018)

Comparative mRNA/micro-RNA co-expression network drives melanomagenesis by promoting epithelial–mesenchymal transition and vasculogenic mimicry signaling
por: He, WenFeng, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_bbftv0rbbus517hgpo450pb4k3