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Engineering Chimeric Antigen Receptor T Cells against Immune Checkpoint Inhibitors PD-1/PD-L1 for Treating Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a 5-year survival rate of 9%. Major obstacles to successful treatment of pancreatic cancer are the immunosuppressive tumor microenvironment (TME) and antigenic complexity or heterogeneity. Programmed death-ligand 1 (PD-L1) is expr...

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Detalles Bibliográficos
Autores principales:	Yang, Ching-Yao, Fan, Ming Huei, Miao, Carol H., Liao, Yi Jen, Yuan, Ray-Hwang, Liu, Chao Lien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321819/ https://www.ncbi.nlm.nih.gov/pubmed/32637575 http://dx.doi.org/10.1016/j.omto.2020.05.009

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