A New Compound with Increased Antitumor Activity by Cotargeting MEK and Pim-1

Feedback circuits are one of the major causes underlying tumor resistance. Thus, compounds that target one oncogenic pathway with simultaneously blocking its compensatory pathway will be of great value for cancer treatment. Here, we develop a new MEK inhibitor designated as KZ-02 that exhibits unexp...

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Detalles Bibliográficos
Autores principales: Li, Yanan, Cheng, Ying, Zhang, Maoqi, He, Xiaoli, Kong, Li, Zhou, Kexiang, Zhou, Yunfu, Li, Lin, Tian, Hongqi, Song, Xiaomin, Cui, Yukun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322072/
https://www.ncbi.nlm.nih.gov/pubmed/32585592
http://dx.doi.org/10.1016/j.isci.2020.101254

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