Cargando…
Hippocampal stiffness in mesial temporal lobe epilepsy measured with MR elastography: Preliminary comparison with healthy participants
Mesial temporal lobe epilepsy (MTLE) is the most common form of refractory epilepsy. Common imaging biomarkers are often not sensitive enough to identify MTLE sufficiently early to facilitate the greatest benefit from surgical or pharmacological intervention. The objective of this work is to establi...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322100/ https://www.ncbi.nlm.nih.gov/pubmed/32585569 http://dx.doi.org/10.1016/j.nicl.2020.102313 |
_version_ | 1783551576346984448 |
---|---|
author | Huesmann, Graham R. Schwarb, Hillary Smith, Daniel R. Pohlig, Ryan T. Anderson, Aaron T. McGarry, Matthew D.J. Paulsen, Keith D. Wszalek, Tracey Mencio Sutton, Bradley P. Johnson, Curtis L. |
author_facet | Huesmann, Graham R. Schwarb, Hillary Smith, Daniel R. Pohlig, Ryan T. Anderson, Aaron T. McGarry, Matthew D.J. Paulsen, Keith D. Wszalek, Tracey Mencio Sutton, Bradley P. Johnson, Curtis L. |
author_sort | Huesmann, Graham R. |
collection | PubMed |
description | Mesial temporal lobe epilepsy (MTLE) is the most common form of refractory epilepsy. Common imaging biomarkers are often not sensitive enough to identify MTLE sufficiently early to facilitate the greatest benefit from surgical or pharmacological intervention. The objective of this work is to establish hippocampal stiffness measured with magnetic resonance elastography (MRE) as a biomarker for MTLE; we hypothesized that the epileptogenic hippocampus in MTLE is stiffer than the non-epileptogenic hippocampus. MRE was used to measure hippocampal stiffness in a group of patients with unilateral MTLE (n = 12) and a group of healthy comparison participants (n = 13). We calculated the ratio of hippocampal stiffness ipsilateral to epileptogenesis to the contralateral side for both groups. We found a higher hippocampal stiffness ratio in patients with MTLE compared with healthy participants (1.14 v. 0.99; p = 0.004), and that stiffness ratio differentiated MTLE from control groups effectively (AUC = 0.85). Hippocampal stiffness ratio, when added to volume ratio, an established MTLE biomarker, significantly improved the ability to differentiate the two groups (p = 0.038). Stiffness measured with MRE is sensitive to hippocampal pathology in MTLE and the addition of MRE to neuroimaging assessments may improve detection and characterization of the disease. |
format | Online Article Text |
id | pubmed-7322100 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-73221002020-06-30 Hippocampal stiffness in mesial temporal lobe epilepsy measured with MR elastography: Preliminary comparison with healthy participants Huesmann, Graham R. Schwarb, Hillary Smith, Daniel R. Pohlig, Ryan T. Anderson, Aaron T. McGarry, Matthew D.J. Paulsen, Keith D. Wszalek, Tracey Mencio Sutton, Bradley P. Johnson, Curtis L. Neuroimage Clin Regular Article Mesial temporal lobe epilepsy (MTLE) is the most common form of refractory epilepsy. Common imaging biomarkers are often not sensitive enough to identify MTLE sufficiently early to facilitate the greatest benefit from surgical or pharmacological intervention. The objective of this work is to establish hippocampal stiffness measured with magnetic resonance elastography (MRE) as a biomarker for MTLE; we hypothesized that the epileptogenic hippocampus in MTLE is stiffer than the non-epileptogenic hippocampus. MRE was used to measure hippocampal stiffness in a group of patients with unilateral MTLE (n = 12) and a group of healthy comparison participants (n = 13). We calculated the ratio of hippocampal stiffness ipsilateral to epileptogenesis to the contralateral side for both groups. We found a higher hippocampal stiffness ratio in patients with MTLE compared with healthy participants (1.14 v. 0.99; p = 0.004), and that stiffness ratio differentiated MTLE from control groups effectively (AUC = 0.85). Hippocampal stiffness ratio, when added to volume ratio, an established MTLE biomarker, significantly improved the ability to differentiate the two groups (p = 0.038). Stiffness measured with MRE is sensitive to hippocampal pathology in MTLE and the addition of MRE to neuroimaging assessments may improve detection and characterization of the disease. Elsevier 2020-06-16 /pmc/articles/PMC7322100/ /pubmed/32585569 http://dx.doi.org/10.1016/j.nicl.2020.102313 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Huesmann, Graham R. Schwarb, Hillary Smith, Daniel R. Pohlig, Ryan T. Anderson, Aaron T. McGarry, Matthew D.J. Paulsen, Keith D. Wszalek, Tracey Mencio Sutton, Bradley P. Johnson, Curtis L. Hippocampal stiffness in mesial temporal lobe epilepsy measured with MR elastography: Preliminary comparison with healthy participants |
title | Hippocampal stiffness in mesial temporal lobe epilepsy measured with MR elastography: Preliminary comparison with healthy participants |
title_full | Hippocampal stiffness in mesial temporal lobe epilepsy measured with MR elastography: Preliminary comparison with healthy participants |
title_fullStr | Hippocampal stiffness in mesial temporal lobe epilepsy measured with MR elastography: Preliminary comparison with healthy participants |
title_full_unstemmed | Hippocampal stiffness in mesial temporal lobe epilepsy measured with MR elastography: Preliminary comparison with healthy participants |
title_short | Hippocampal stiffness in mesial temporal lobe epilepsy measured with MR elastography: Preliminary comparison with healthy participants |
title_sort | hippocampal stiffness in mesial temporal lobe epilepsy measured with mr elastography: preliminary comparison with healthy participants |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322100/ https://www.ncbi.nlm.nih.gov/pubmed/32585569 http://dx.doi.org/10.1016/j.nicl.2020.102313 |
work_keys_str_mv | AT huesmanngrahamr hippocampalstiffnessinmesialtemporallobeepilepsymeasuredwithmrelastographypreliminarycomparisonwithhealthyparticipants AT schwarbhillary hippocampalstiffnessinmesialtemporallobeepilepsymeasuredwithmrelastographypreliminarycomparisonwithhealthyparticipants AT smithdanielr hippocampalstiffnessinmesialtemporallobeepilepsymeasuredwithmrelastographypreliminarycomparisonwithhealthyparticipants AT pohligryant hippocampalstiffnessinmesialtemporallobeepilepsymeasuredwithmrelastographypreliminarycomparisonwithhealthyparticipants AT andersonaaront hippocampalstiffnessinmesialtemporallobeepilepsymeasuredwithmrelastographypreliminarycomparisonwithhealthyparticipants AT mcgarrymatthewdj hippocampalstiffnessinmesialtemporallobeepilepsymeasuredwithmrelastographypreliminarycomparisonwithhealthyparticipants AT paulsenkeithd hippocampalstiffnessinmesialtemporallobeepilepsymeasuredwithmrelastographypreliminarycomparisonwithhealthyparticipants AT wszalektraceymencio hippocampalstiffnessinmesialtemporallobeepilepsymeasuredwithmrelastographypreliminarycomparisonwithhealthyparticipants AT suttonbradleyp hippocampalstiffnessinmesialtemporallobeepilepsymeasuredwithmrelastographypreliminarycomparisonwithhealthyparticipants AT johnsoncurtisl hippocampalstiffnessinmesialtemporallobeepilepsymeasuredwithmrelastographypreliminarycomparisonwithhealthyparticipants |