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Synaptic Connections of Aromatase Circuits in the Medial Amygdala Are Sex Specific
The brains of male and female mice are shaped by genetics and hormones during development. The enzyme aromatase helps establish sex differences in social behaviors and in the neural circuits that produce these behaviors. The medial amygdala of mice contains a large population of aromatase neurons an...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Neuroscience
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322293/ https://www.ncbi.nlm.nih.gov/pubmed/32471845 http://dx.doi.org/10.1523/ENEURO.0489-19.2020 |
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author | Billing, Addison Henrique Correia, Marcelo Kelly, Diane A. Li, Geng-Lin Bergan, Joseph F. |
author_facet | Billing, Addison Henrique Correia, Marcelo Kelly, Diane A. Li, Geng-Lin Bergan, Joseph F. |
author_sort | Billing, Addison |
collection | PubMed |
description | The brains of male and female mice are shaped by genetics and hormones during development. The enzyme aromatase helps establish sex differences in social behaviors and in the neural circuits that produce these behaviors. The medial amygdala of mice contains a large population of aromatase neurons and is a critical hub in the social behavior network. Moreover, the neural representation of social stimuli in the medial amygdala displays clear sex differences that track developmental changes in social behaviors. Here, we identify a potential anatomic basis for those sex differences. We found that sensory input from the accessory olfactory bulb (AOB) to aromatase neurons is derived nearly exclusively from the anterior AOB, which selectively responds to chemosensory cues from conspecific animals. Through the coordinated use of mouse transgenics and viral-based circuit-tracing strategies, we demonstrate a clear sex difference in the volume of synapses connecting the accessory olfactory bulb to aromatase-expressing neurons in the medial amygdala of male versus female mice. This difference in anatomy likely mediates, at least in part, sex differences in medial amygdala-mediated social behaviors. |
format | Online Article Text |
id | pubmed-7322293 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Society for Neuroscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-73222932020-06-29 Synaptic Connections of Aromatase Circuits in the Medial Amygdala Are Sex Specific Billing, Addison Henrique Correia, Marcelo Kelly, Diane A. Li, Geng-Lin Bergan, Joseph F. eNeuro Research Article: New Research The brains of male and female mice are shaped by genetics and hormones during development. The enzyme aromatase helps establish sex differences in social behaviors and in the neural circuits that produce these behaviors. The medial amygdala of mice contains a large population of aromatase neurons and is a critical hub in the social behavior network. Moreover, the neural representation of social stimuli in the medial amygdala displays clear sex differences that track developmental changes in social behaviors. Here, we identify a potential anatomic basis for those sex differences. We found that sensory input from the accessory olfactory bulb (AOB) to aromatase neurons is derived nearly exclusively from the anterior AOB, which selectively responds to chemosensory cues from conspecific animals. Through the coordinated use of mouse transgenics and viral-based circuit-tracing strategies, we demonstrate a clear sex difference in the volume of synapses connecting the accessory olfactory bulb to aromatase-expressing neurons in the medial amygdala of male versus female mice. This difference in anatomy likely mediates, at least in part, sex differences in medial amygdala-mediated social behaviors. Society for Neuroscience 2020-06-17 /pmc/articles/PMC7322293/ /pubmed/32471845 http://dx.doi.org/10.1523/ENEURO.0489-19.2020 Text en Copyright © 2020 Billing et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Research Article: New Research Billing, Addison Henrique Correia, Marcelo Kelly, Diane A. Li, Geng-Lin Bergan, Joseph F. Synaptic Connections of Aromatase Circuits in the Medial Amygdala Are Sex Specific |
title | Synaptic Connections of Aromatase Circuits in the Medial Amygdala Are Sex Specific |
title_full | Synaptic Connections of Aromatase Circuits in the Medial Amygdala Are Sex Specific |
title_fullStr | Synaptic Connections of Aromatase Circuits in the Medial Amygdala Are Sex Specific |
title_full_unstemmed | Synaptic Connections of Aromatase Circuits in the Medial Amygdala Are Sex Specific |
title_short | Synaptic Connections of Aromatase Circuits in the Medial Amygdala Are Sex Specific |
title_sort | synaptic connections of aromatase circuits in the medial amygdala are sex specific |
topic | Research Article: New Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322293/ https://www.ncbi.nlm.nih.gov/pubmed/32471845 http://dx.doi.org/10.1523/ENEURO.0489-19.2020 |
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