A case of ALK-rearranged lung adenocarcinoma associated with syndrome of inappropriate antidiuretic hormone

A 60-year-old man with a history of smoking was transferred to our hospital for consciousness disorder. A diagnosis of ALK-rearranged lung adenocarcinoma associated with a paraneoplastic electrolytic disorder was made following a cutaneous needle biopsy. Both the primary lung lesion and multiple met...

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Detalles Bibliográficos
Autores principales: Miyashita, Yoshihiro, Hanawa, Kotaro, Kobayashi, Hiroaki, Kumagai, Takashi, Inomata, Kie, Tsutsui, Toshiharu, Kakizaki, Yumiko, Oyama, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322342/
https://www.ncbi.nlm.nih.gov/pubmed/32612920
http://dx.doi.org/10.1016/j.rmcr.2020.101136
Descripción
Sumario:A 60-year-old man with a history of smoking was transferred to our hospital for consciousness disorder. A diagnosis of ALK-rearranged lung adenocarcinoma associated with a paraneoplastic electrolytic disorder was made following a cutaneous needle biopsy. Both the primary lung lesion and multiple metastases shrunk and his electrolytic disorder resolved after the introduction of a first-line molecular-targeted drug chemotherapy with crizotinib. We herein report a case of ALK-rearranged lung adenocarcinoma accompanied by SIADH, successfully treated with crizotinib.

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