A case of ALK-rearranged lung adenocarcinoma associated with syndrome of inappropriate antidiuretic hormone

A 60-year-old man with a history of smoking was transferred to our hospital for consciousness disorder. A diagnosis of ALK-rearranged lung adenocarcinoma associated with a paraneoplastic electrolytic disorder was made following a cutaneous needle biopsy. Both the primary lung lesion and multiple met...

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Autores principales: Miyashita, Yoshihiro, Hanawa, Kotaro, Kobayashi, Hiroaki, Kumagai, Takashi, Inomata, Kie, Tsutsui, Toshiharu, Kakizaki, Yumiko, Oyama, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322342/
https://www.ncbi.nlm.nih.gov/pubmed/32612920
http://dx.doi.org/10.1016/j.rmcr.2020.101136
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author Miyashita, Yoshihiro
Hanawa, Kotaro
Kobayashi, Hiroaki
Kumagai, Takashi
Inomata, Kie
Tsutsui, Toshiharu
Kakizaki, Yumiko
Oyama, Toshio
author_facet Miyashita, Yoshihiro
Hanawa, Kotaro
Kobayashi, Hiroaki
Kumagai, Takashi
Inomata, Kie
Tsutsui, Toshiharu
Kakizaki, Yumiko
Oyama, Toshio
author_sort Miyashita, Yoshihiro
collection PubMed
description A 60-year-old man with a history of smoking was transferred to our hospital for consciousness disorder. A diagnosis of ALK-rearranged lung adenocarcinoma associated with a paraneoplastic electrolytic disorder was made following a cutaneous needle biopsy. Both the primary lung lesion and multiple metastases shrunk and his electrolytic disorder resolved after the introduction of a first-line molecular-targeted drug chemotherapy with crizotinib. We herein report a case of ALK-rearranged lung adenocarcinoma accompanied by SIADH, successfully treated with crizotinib.
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spelling pubmed-73223422020-06-30 A case of ALK-rearranged lung adenocarcinoma associated with syndrome of inappropriate antidiuretic hormone Miyashita, Yoshihiro Hanawa, Kotaro Kobayashi, Hiroaki Kumagai, Takashi Inomata, Kie Tsutsui, Toshiharu Kakizaki, Yumiko Oyama, Toshio Respir Med Case Rep Case Report A 60-year-old man with a history of smoking was transferred to our hospital for consciousness disorder. A diagnosis of ALK-rearranged lung adenocarcinoma associated with a paraneoplastic electrolytic disorder was made following a cutaneous needle biopsy. Both the primary lung lesion and multiple metastases shrunk and his electrolytic disorder resolved after the introduction of a first-line molecular-targeted drug chemotherapy with crizotinib. We herein report a case of ALK-rearranged lung adenocarcinoma accompanied by SIADH, successfully treated with crizotinib. Elsevier 2020-06-17 /pmc/articles/PMC7322342/ /pubmed/32612920 http://dx.doi.org/10.1016/j.rmcr.2020.101136 Text en © 2020 The Authors. Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Miyashita, Yoshihiro
Hanawa, Kotaro
Kobayashi, Hiroaki
Kumagai, Takashi
Inomata, Kie
Tsutsui, Toshiharu
Kakizaki, Yumiko
Oyama, Toshio
A case of ALK-rearranged lung adenocarcinoma associated with syndrome of inappropriate antidiuretic hormone
title A case of ALK-rearranged lung adenocarcinoma associated with syndrome of inappropriate antidiuretic hormone
title_full A case of ALK-rearranged lung adenocarcinoma associated with syndrome of inappropriate antidiuretic hormone
title_fullStr A case of ALK-rearranged lung adenocarcinoma associated with syndrome of inappropriate antidiuretic hormone
title_full_unstemmed A case of ALK-rearranged lung adenocarcinoma associated with syndrome of inappropriate antidiuretic hormone
title_short A case of ALK-rearranged lung adenocarcinoma associated with syndrome of inappropriate antidiuretic hormone
title_sort case of alk-rearranged lung adenocarcinoma associated with syndrome of inappropriate antidiuretic hormone
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322342/
https://www.ncbi.nlm.nih.gov/pubmed/32612920
http://dx.doi.org/10.1016/j.rmcr.2020.101136
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