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Diffuse alveolar hemorrhage with histopathologic manifestations of pulmonary capillaritis: Three case reports
BACKGROUND: Diffuse alveolar hemorrhage (DAH) is a multicause pulmonary capillary hemorrhage or pulmonary vascular small vessel injury (mainly capillaries, including arteries and veins), causing pulmonary microcirculation blood to accumulate in the alveolar space. DAH is classified by the histologic...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322415/ https://www.ncbi.nlm.nih.gov/pubmed/32607347 http://dx.doi.org/10.12998/wjcc.v8.i12.2662 |
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author | Xie, Jun Zhao, Ying-Yue Liu, Jing Nong, Guang-Min |
author_facet | Xie, Jun Zhao, Ying-Yue Liu, Jing Nong, Guang-Min |
author_sort | Xie, Jun |
collection | PubMed |
description | BACKGROUND: Diffuse alveolar hemorrhage (DAH) is a multicause pulmonary capillary hemorrhage or pulmonary vascular small vessel injury (mainly capillaries, including arteries and veins), causing pulmonary microcirculation blood to accumulate in the alveolar space. DAH is classified by the histological absence or presence of pulmonary capillaritis (PC) and is rarely reported in the literature. CASE SUMMARY: This is a report of three girls aged 6-11 years with DAH and PC. Two patients had decreased hemoglobin and one had increased erythrocyte sedimentation rate. High-resolution computed tomography showed bilateral diffuse pulmonary infiltrate, and diagnosis of PC was confirmed by lung biopsy. Immunofluorescence test in one case showed granular IgG and a small amount of granular IgA deposit on the alveolar walls, and was negative in the other two cases, describing isolated pauci-immune PC. Treatment was with glucocorticoid alone or combination with immunosuppressants, and the symptoms resolved in all patients. CONCLUSION: PC is classified as isolated and immune-mediated PC associated with systemic disease. It can be controlled in most children with glucocorticoid alone or combined with immunosuppressants. |
format | Online Article Text |
id | pubmed-7322415 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-73224152020-06-29 Diffuse alveolar hemorrhage with histopathologic manifestations of pulmonary capillaritis: Three case reports Xie, Jun Zhao, Ying-Yue Liu, Jing Nong, Guang-Min World J Clin Cases Case Report BACKGROUND: Diffuse alveolar hemorrhage (DAH) is a multicause pulmonary capillary hemorrhage or pulmonary vascular small vessel injury (mainly capillaries, including arteries and veins), causing pulmonary microcirculation blood to accumulate in the alveolar space. DAH is classified by the histological absence or presence of pulmonary capillaritis (PC) and is rarely reported in the literature. CASE SUMMARY: This is a report of three girls aged 6-11 years with DAH and PC. Two patients had decreased hemoglobin and one had increased erythrocyte sedimentation rate. High-resolution computed tomography showed bilateral diffuse pulmonary infiltrate, and diagnosis of PC was confirmed by lung biopsy. Immunofluorescence test in one case showed granular IgG and a small amount of granular IgA deposit on the alveolar walls, and was negative in the other two cases, describing isolated pauci-immune PC. Treatment was with glucocorticoid alone or combination with immunosuppressants, and the symptoms resolved in all patients. CONCLUSION: PC is classified as isolated and immune-mediated PC associated with systemic disease. It can be controlled in most children with glucocorticoid alone or combined with immunosuppressants. Baishideng Publishing Group Inc 2020-06-26 2020-06-26 /pmc/articles/PMC7322415/ /pubmed/32607347 http://dx.doi.org/10.12998/wjcc.v8.i12.2662 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Case Report Xie, Jun Zhao, Ying-Yue Liu, Jing Nong, Guang-Min Diffuse alveolar hemorrhage with histopathologic manifestations of pulmonary capillaritis: Three case reports |
title | Diffuse alveolar hemorrhage with histopathologic manifestations of pulmonary capillaritis: Three case reports |
title_full | Diffuse alveolar hemorrhage with histopathologic manifestations of pulmonary capillaritis: Three case reports |
title_fullStr | Diffuse alveolar hemorrhage with histopathologic manifestations of pulmonary capillaritis: Three case reports |
title_full_unstemmed | Diffuse alveolar hemorrhage with histopathologic manifestations of pulmonary capillaritis: Three case reports |
title_short | Diffuse alveolar hemorrhage with histopathologic manifestations of pulmonary capillaritis: Three case reports |
title_sort | diffuse alveolar hemorrhage with histopathologic manifestations of pulmonary capillaritis: three case reports |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322415/ https://www.ncbi.nlm.nih.gov/pubmed/32607347 http://dx.doi.org/10.12998/wjcc.v8.i12.2662 |
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