Cargando…

Evasins: Tick Salivary Proteins that Inhibit Mammalian Chemokines

Ticks are hematophagous arachnids that parasitize mammals and other hosts, feeding on their blood. Ticks secrete numerous salivary factors that enhance host blood flow or suppress the host inflammatory response. The recruitment of leukocytes, a hallmark of inflammation, is regulated by chemokines, w...

Descripción completa

Detalles Bibliográficos
Autores principales: Bhusal, Ram Prasad, Eaton, James R.O., Chowdhury, Sayeeda T., Power, Christine A., Proudfoot, Amanda E.I., Stone, Martin J., Bhattacharya, Shoumo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Trends Journals 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322545/
https://www.ncbi.nlm.nih.gov/pubmed/31679840
http://dx.doi.org/10.1016/j.tibs.2019.10.003
_version_ 1783551663986966528
author Bhusal, Ram Prasad
Eaton, James R.O.
Chowdhury, Sayeeda T.
Power, Christine A.
Proudfoot, Amanda E.I.
Stone, Martin J.
Bhattacharya, Shoumo
author_facet Bhusal, Ram Prasad
Eaton, James R.O.
Chowdhury, Sayeeda T.
Power, Christine A.
Proudfoot, Amanda E.I.
Stone, Martin J.
Bhattacharya, Shoumo
author_sort Bhusal, Ram Prasad
collection PubMed
description Ticks are hematophagous arachnids that parasitize mammals and other hosts, feeding on their blood. Ticks secrete numerous salivary factors that enhance host blood flow or suppress the host inflammatory response. The recruitment of leukocytes, a hallmark of inflammation, is regulated by chemokines, which activate chemokine receptors on the leukocytes. Ticks target this process by secreting glycoproteins called Evasins, which bind to chemokines and prevent leukocyte recruitment. This review describes the recent discovery of numerous Evasins produced by ticks, their classification into two structural and functional classes, and the efficacy of Evasins in animal models of inflammatory diseases. The review also proposes a standard nomenclature system for Evasins and discusses the potential of repurposing or engineering Evasins as therapeutic anti-inflammatory agents.
format Online
Article
Text
id pubmed-7322545
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier Trends Journals
record_format MEDLINE/PubMed
spelling pubmed-73225452020-06-30 Evasins: Tick Salivary Proteins that Inhibit Mammalian Chemokines Bhusal, Ram Prasad Eaton, James R.O. Chowdhury, Sayeeda T. Power, Christine A. Proudfoot, Amanda E.I. Stone, Martin J. Bhattacharya, Shoumo Trends Biochem Sci Article Ticks are hematophagous arachnids that parasitize mammals and other hosts, feeding on their blood. Ticks secrete numerous salivary factors that enhance host blood flow or suppress the host inflammatory response. The recruitment of leukocytes, a hallmark of inflammation, is regulated by chemokines, which activate chemokine receptors on the leukocytes. Ticks target this process by secreting glycoproteins called Evasins, which bind to chemokines and prevent leukocyte recruitment. This review describes the recent discovery of numerous Evasins produced by ticks, their classification into two structural and functional classes, and the efficacy of Evasins in animal models of inflammatory diseases. The review also proposes a standard nomenclature system for Evasins and discusses the potential of repurposing or engineering Evasins as therapeutic anti-inflammatory agents. Elsevier Trends Journals 2020-02 /pmc/articles/PMC7322545/ /pubmed/31679840 http://dx.doi.org/10.1016/j.tibs.2019.10.003 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bhusal, Ram Prasad
Eaton, James R.O.
Chowdhury, Sayeeda T.
Power, Christine A.
Proudfoot, Amanda E.I.
Stone, Martin J.
Bhattacharya, Shoumo
Evasins: Tick Salivary Proteins that Inhibit Mammalian Chemokines
title Evasins: Tick Salivary Proteins that Inhibit Mammalian Chemokines
title_full Evasins: Tick Salivary Proteins that Inhibit Mammalian Chemokines
title_fullStr Evasins: Tick Salivary Proteins that Inhibit Mammalian Chemokines
title_full_unstemmed Evasins: Tick Salivary Proteins that Inhibit Mammalian Chemokines
title_short Evasins: Tick Salivary Proteins that Inhibit Mammalian Chemokines
title_sort evasins: tick salivary proteins that inhibit mammalian chemokines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322545/
https://www.ncbi.nlm.nih.gov/pubmed/31679840
http://dx.doi.org/10.1016/j.tibs.2019.10.003
work_keys_str_mv AT bhusalramprasad evasinsticksalivaryproteinsthatinhibitmammalianchemokines
AT eatonjamesro evasinsticksalivaryproteinsthatinhibitmammalianchemokines
AT chowdhurysayeedat evasinsticksalivaryproteinsthatinhibitmammalianchemokines
AT powerchristinea evasinsticksalivaryproteinsthatinhibitmammalianchemokines
AT proudfootamandaei evasinsticksalivaryproteinsthatinhibitmammalianchemokines
AT stonemartinj evasinsticksalivaryproteinsthatinhibitmammalianchemokines
AT bhattacharyashoumo evasinsticksalivaryproteinsthatinhibitmammalianchemokines