MxB impedes the NUP358-mediated HIV-1 pre-integration complex nuclear import and viral replication cooperatively with CPSF6

BACKGROUND: The human myxovirus resistance 2 (Mx2/MxB) protein was originally found to regulate cytoplasmic-nuclear transport but was recently reported to restrict HIV-1 replication by binding to HIV-1 capsid (CA), preventing uncoating, the nuclear import of pre-integration complex (PIC) and viral D...

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Detalles Bibliográficos
Autores principales: Xie, Linlin, Chen, Lang, Zhong, Chaojie, Yu, Ting, Ju, Zhao, Wang, Meirong, Xiong, Hairong, Zeng, Yan, Wang, Jianhua, Hu, Haitao, Hou, Wei, Feng, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322711/
https://www.ncbi.nlm.nih.gov/pubmed/32600399
http://dx.doi.org/10.1186/s12977-020-00524-2

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