The α7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation

BACKGROUND: Oxygen therapy, using supraphysiological concentrations of oxygen (hyperoxia), is routinely administered to patients who require respiratory support including mechanical ventilation (MV). However, prolonged exposure to hyperoxia results in acute lung injury (ALI) and accumulation of high...

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Detalles Bibliográficos
Autores principales: Sitapara, Ravikumar A., Gauthier, Alex G., Valdés-Ferrer, Sergio I., Lin, Mosi, Patel, Vivek, Wang, Mao, Martino, Ashley T., Perron, Jeanette C., Ashby, Charles R., Tracey, Kevin J., Pavlov, Valentin A., Mantell, Lin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322715/
https://www.ncbi.nlm.nih.gov/pubmed/32600307
http://dx.doi.org/10.1186/s10020-020-00177-z

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