Allele-specific DNA methylation is increased in cancers and its dense mapping in normal plus neoplastic cells increases the yield of disease-associated regulatory SNPs

BACKGROUND: Mapping of allele-specific DNA methylation (ASM) can be a post-GWAS strategy for localizing regulatory sequence polymorphisms (rSNPs). The advantages of this approach, and the mechanisms underlying ASM in normal and neoplastic cells, remain to be clarified. RESULTS: We perform whole geno...

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Detalles Bibliográficos
Autores principales: Do, Catherine, Dumont, Emmanuel L. P., Salas, Martha, Castano, Angelica, Mujahed, Huthayfa, Maldonado, Leonel, Singh, Arunjot, DaSilva-Arnold, Sonia C., Bhagat, Govind, Lehman, Soren, Christiano, Angela M., Madhavan, Subha, Nagy, Peter L., Green, Peter H. R., Feinman, Rena, Trimble, Cornelia, Illsley, Nicholas P., Marder, Karen, Honig, Lawrence, Monk, Catherine, Goy, Andre, Chow, Kar, Goldlust, Samuel, Kaptain, George, Siegel, David, Tycko, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322865/
https://www.ncbi.nlm.nih.gov/pubmed/32594908
http://dx.doi.org/10.1186/s13059-020-02059-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322865/
https://www.ncbi.nlm.nih.gov/pubmed/32594908
http://dx.doi.org/10.1186/s13059-020-02059-3

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