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T-Cell Mechanobiology: Force Sensation, Potentiation, and Translation

A T cell is a sensitive self-referential mechanical sensor. Mechanical forces influence the recognition, activation, differentiation, and function throughout the lifetime of a T cell. T cells constantly perceive and respond to physical stimuli through their surface receptors, cytoskeleton, and subce...

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Detalles Bibliográficos
Autores principales: Harrison, Devin L., Fang, Yun, Huang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323161/
https://www.ncbi.nlm.nih.gov/pubmed/32601597
http://dx.doi.org/10.3389/fphy.2019.00045
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author Harrison, Devin L.
Fang, Yun
Huang, Jun
author_facet Harrison, Devin L.
Fang, Yun
Huang, Jun
author_sort Harrison, Devin L.
collection PubMed
description A T cell is a sensitive self-referential mechanical sensor. Mechanical forces influence the recognition, activation, differentiation, and function throughout the lifetime of a T cell. T cells constantly perceive and respond to physical stimuli through their surface receptors, cytoskeleton, and subcellular structures. Surface receptors receive physical cues in the form of forces generated through receptor-ligand binding events, which are dynamically regulated by contact tension, shear stress, and substrate rigidity. The resulting mechanotransduction not only influences T-cell recognition and signaling but also possibly modulates cell metabolism and gene expression. Moreover, forces also dynamically regulate the deformation, organization, and translocation of cytoskeleton and subcellular structures, leading to changes in T-cell mobility, migration, and infiltration. However, the roles and mechanisms of how mechanical forces modulate T-cell recognition, signaling, metabolism, and gene expression, are largely unknown and underappreciated. Here, we review recent technological and scientific advances in T-cell mechanobiology, discuss possible roles and mechanisms of T-cell mechanotransduction, and propose new research directions of this emerging field in health and disease.
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spelling pubmed-73231612020-06-29 T-Cell Mechanobiology: Force Sensation, Potentiation, and Translation Harrison, Devin L. Fang, Yun Huang, Jun Front Phys Article A T cell is a sensitive self-referential mechanical sensor. Mechanical forces influence the recognition, activation, differentiation, and function throughout the lifetime of a T cell. T cells constantly perceive and respond to physical stimuli through their surface receptors, cytoskeleton, and subcellular structures. Surface receptors receive physical cues in the form of forces generated through receptor-ligand binding events, which are dynamically regulated by contact tension, shear stress, and substrate rigidity. The resulting mechanotransduction not only influences T-cell recognition and signaling but also possibly modulates cell metabolism and gene expression. Moreover, forces also dynamically regulate the deformation, organization, and translocation of cytoskeleton and subcellular structures, leading to changes in T-cell mobility, migration, and infiltration. However, the roles and mechanisms of how mechanical forces modulate T-cell recognition, signaling, metabolism, and gene expression, are largely unknown and underappreciated. Here, we review recent technological and scientific advances in T-cell mechanobiology, discuss possible roles and mechanisms of T-cell mechanotransduction, and propose new research directions of this emerging field in health and disease. 2019-04-02 2019-04 /pmc/articles/PMC7323161/ /pubmed/32601597 http://dx.doi.org/10.3389/fphy.2019.00045 Text en This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Article
Harrison, Devin L.
Fang, Yun
Huang, Jun
T-Cell Mechanobiology: Force Sensation, Potentiation, and Translation
title T-Cell Mechanobiology: Force Sensation, Potentiation, and Translation
title_full T-Cell Mechanobiology: Force Sensation, Potentiation, and Translation
title_fullStr T-Cell Mechanobiology: Force Sensation, Potentiation, and Translation
title_full_unstemmed T-Cell Mechanobiology: Force Sensation, Potentiation, and Translation
title_short T-Cell Mechanobiology: Force Sensation, Potentiation, and Translation
title_sort t-cell mechanobiology: force sensation, potentiation, and translation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323161/
https://www.ncbi.nlm.nih.gov/pubmed/32601597
http://dx.doi.org/10.3389/fphy.2019.00045
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