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Impact of Disease on Plasma and Lung Exposure of Chloroquine, Hydroxychloroquine and Azithromycin: Application of PBPK Modeling

We use a mechanistic lung model to demonstrate that accumulation of chloroquine (CQ), hydroxychloroquine (HCQ), and azithromycin (AZ) in the lungs is sensitive to changes in lung pH, a parameter that can be affected in patients with coronavirus disease 2019 (COVID‐19). A reduction in pH from 6.7 to...

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Detalles Bibliográficos
Autores principales:	Rowland Yeo, Karen, Zhang, Mian, Pan, Xian, Ban Ke, Alice, Jones, Hannah M., Wesche, David, Almond, Lisa M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323312/ https://www.ncbi.nlm.nih.gov/pubmed/32531808 http://dx.doi.org/10.1002/cpt.1955

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