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Coronavirus disease 2019 (COVID-19): cytokine storms, hyper-inflammatory phenotypes, and acute respiratory distress syndrome

Coronavirus Disease 2019 (COVID-19) was first identified in China at the end of 2019. Acute respiratory distress syndrome (ARDS) represents the most common and serious complication of COVID-19. Cytokine storms are a pathophysiological feature of COVID-19 and play an important role in distinguishing...

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Autores principales: Lin, Shi-hui, Zhao, Yi-si, Zhou, Dai-xing, Zhou, Fa-chun, Xu, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323676/
https://www.ncbi.nlm.nih.gov/pubmed/32837983
http://dx.doi.org/10.1016/j.gendis.2020.06.009
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author Lin, Shi-hui
Zhao, Yi-si
Zhou, Dai-xing
Zhou, Fa-chun
Xu, Fang
author_facet Lin, Shi-hui
Zhao, Yi-si
Zhou, Dai-xing
Zhou, Fa-chun
Xu, Fang
author_sort Lin, Shi-hui
collection PubMed
description Coronavirus Disease 2019 (COVID-19) was first identified in China at the end of 2019. Acute respiratory distress syndrome (ARDS) represents the most common and serious complication of COVID-19. Cytokine storms are a pathophysiological feature of COVID-19 and play an important role in distinguishing hyper-inflammatory subphenotypes of ARDS. Accordingly, in this review, we focus on hyper-inflammatory host responses in ARDS that play a critical role in the differentiated development of COVID-19. Furthermore, we discuss inflammation-related indicators that have the potential to identify hyper-inflammatory subphenotypes of COVID-19, especially for those with a high risk of ARDS. Finally, we explore the possibility of improving the quality of monitoring and treatment of COVID-19 patients and in reducing the incidence of critical illness and mortality via better distinguishing hyper- and hypo-inflammatory subphenotypes of COVID-19.
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spelling pubmed-73236762020-06-30 Coronavirus disease 2019 (COVID-19): cytokine storms, hyper-inflammatory phenotypes, and acute respiratory distress syndrome Lin, Shi-hui Zhao, Yi-si Zhou, Dai-xing Zhou, Fa-chun Xu, Fang Genes Dis Review Article Coronavirus Disease 2019 (COVID-19) was first identified in China at the end of 2019. Acute respiratory distress syndrome (ARDS) represents the most common and serious complication of COVID-19. Cytokine storms are a pathophysiological feature of COVID-19 and play an important role in distinguishing hyper-inflammatory subphenotypes of ARDS. Accordingly, in this review, we focus on hyper-inflammatory host responses in ARDS that play a critical role in the differentiated development of COVID-19. Furthermore, we discuss inflammation-related indicators that have the potential to identify hyper-inflammatory subphenotypes of COVID-19, especially for those with a high risk of ARDS. Finally, we explore the possibility of improving the quality of monitoring and treatment of COVID-19 patients and in reducing the incidence of critical illness and mortality via better distinguishing hyper- and hypo-inflammatory subphenotypes of COVID-19. Chongqing Medical University 2020-06-29 /pmc/articles/PMC7323676/ /pubmed/32837983 http://dx.doi.org/10.1016/j.gendis.2020.06.009 Text en © 2020 Chongqing Medical University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Lin, Shi-hui
Zhao, Yi-si
Zhou, Dai-xing
Zhou, Fa-chun
Xu, Fang
Coronavirus disease 2019 (COVID-19): cytokine storms, hyper-inflammatory phenotypes, and acute respiratory distress syndrome
title Coronavirus disease 2019 (COVID-19): cytokine storms, hyper-inflammatory phenotypes, and acute respiratory distress syndrome
title_full Coronavirus disease 2019 (COVID-19): cytokine storms, hyper-inflammatory phenotypes, and acute respiratory distress syndrome
title_fullStr Coronavirus disease 2019 (COVID-19): cytokine storms, hyper-inflammatory phenotypes, and acute respiratory distress syndrome
title_full_unstemmed Coronavirus disease 2019 (COVID-19): cytokine storms, hyper-inflammatory phenotypes, and acute respiratory distress syndrome
title_short Coronavirus disease 2019 (COVID-19): cytokine storms, hyper-inflammatory phenotypes, and acute respiratory distress syndrome
title_sort coronavirus disease 2019 (covid-19): cytokine storms, hyper-inflammatory phenotypes, and acute respiratory distress syndrome
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323676/
https://www.ncbi.nlm.nih.gov/pubmed/32837983
http://dx.doi.org/10.1016/j.gendis.2020.06.009
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