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Supraspinal and Afferent Signaling Facilitate Spinal Sensorimotor Network Excitability After Discomplete Spinal Cord Injury: A Case Report
OBJECTIVE: In this study, we evaluated the role of residual supraspinal and afferent signaling and their convergence on the sublesional spinal network in subject diagnosed with complete paralysis (AIS-A). METHODS: A combination of electrophysiologic techniques with positional changes and subject-dri...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323764/ https://www.ncbi.nlm.nih.gov/pubmed/32655351 http://dx.doi.org/10.3389/fnins.2020.00552 |
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author | Militskova, Alena Mukhametova, Elvira Fatykhova, Elsa Sharifullin, Safar Cuellar, Carlos A. Calvert, Jonathan S. Grahn, Peter J. Baltina, Tatiana Lavrov, Igor |
author_facet | Militskova, Alena Mukhametova, Elvira Fatykhova, Elsa Sharifullin, Safar Cuellar, Carlos A. Calvert, Jonathan S. Grahn, Peter J. Baltina, Tatiana Lavrov, Igor |
author_sort | Militskova, Alena |
collection | PubMed |
description | OBJECTIVE: In this study, we evaluated the role of residual supraspinal and afferent signaling and their convergence on the sublesional spinal network in subject diagnosed with complete paralysis (AIS-A). METHODS: A combination of electrophysiologic techniques with positional changes and subject-driven reinforcement maneuvers was implemented in this study. Electrical stimulation was applied transcutaneously at the T9-L2 vertebra levels and the spinal cord motor evoked potentials (SEMP) were recorded from leg muscles. To test the influence of positional changes, the subject was placed in (i) supine, (ii) upright with partial body weight bearing and (iii) vertically suspended without body weight bearing positions. RESULTS: Increase in amplitude of SEMP was observed during transition from supine to upright position, supporting the role of sensory input in lumbosacral network excitability. Additionally, amplitudes of SEMP were facilitated during reinforcement maneuvers, indicating a supralesional influence on sub-lesional network. After initial assessment, subject underwent rehabilitation therapy with following electrophysiological testing that reviled facilitation of SEMP. CONCLUSION: These results demonstrate that combination of electrophysiological techniques with positional and reinforcement maneuvers can add to the diagnostics of discomplete SCI. These findings also support an idea that integration of supraspinal and afferent information on sub-lesional circuitry plays a critical role in facilitation of spinal sensorimotor network in discomplete SCI. |
format | Online Article Text |
id | pubmed-7323764 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73237642020-07-09 Supraspinal and Afferent Signaling Facilitate Spinal Sensorimotor Network Excitability After Discomplete Spinal Cord Injury: A Case Report Militskova, Alena Mukhametova, Elvira Fatykhova, Elsa Sharifullin, Safar Cuellar, Carlos A. Calvert, Jonathan S. Grahn, Peter J. Baltina, Tatiana Lavrov, Igor Front Neurosci Neuroscience OBJECTIVE: In this study, we evaluated the role of residual supraspinal and afferent signaling and their convergence on the sublesional spinal network in subject diagnosed with complete paralysis (AIS-A). METHODS: A combination of electrophysiologic techniques with positional changes and subject-driven reinforcement maneuvers was implemented in this study. Electrical stimulation was applied transcutaneously at the T9-L2 vertebra levels and the spinal cord motor evoked potentials (SEMP) were recorded from leg muscles. To test the influence of positional changes, the subject was placed in (i) supine, (ii) upright with partial body weight bearing and (iii) vertically suspended without body weight bearing positions. RESULTS: Increase in amplitude of SEMP was observed during transition from supine to upright position, supporting the role of sensory input in lumbosacral network excitability. Additionally, amplitudes of SEMP were facilitated during reinforcement maneuvers, indicating a supralesional influence on sub-lesional network. After initial assessment, subject underwent rehabilitation therapy with following electrophysiological testing that reviled facilitation of SEMP. CONCLUSION: These results demonstrate that combination of electrophysiological techniques with positional and reinforcement maneuvers can add to the diagnostics of discomplete SCI. These findings also support an idea that integration of supraspinal and afferent information on sub-lesional circuitry plays a critical role in facilitation of spinal sensorimotor network in discomplete SCI. Frontiers Media S.A. 2020-06-22 /pmc/articles/PMC7323764/ /pubmed/32655351 http://dx.doi.org/10.3389/fnins.2020.00552 Text en Copyright © 2020 Militskova, Mukhametova, Fatykhova, Sharifullin, Cuellar, Calvert, Grahn, Baltina and Lavrov. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Militskova, Alena Mukhametova, Elvira Fatykhova, Elsa Sharifullin, Safar Cuellar, Carlos A. Calvert, Jonathan S. Grahn, Peter J. Baltina, Tatiana Lavrov, Igor Supraspinal and Afferent Signaling Facilitate Spinal Sensorimotor Network Excitability After Discomplete Spinal Cord Injury: A Case Report |
title | Supraspinal and Afferent Signaling Facilitate Spinal Sensorimotor Network Excitability After Discomplete Spinal Cord Injury: A Case Report |
title_full | Supraspinal and Afferent Signaling Facilitate Spinal Sensorimotor Network Excitability After Discomplete Spinal Cord Injury: A Case Report |
title_fullStr | Supraspinal and Afferent Signaling Facilitate Spinal Sensorimotor Network Excitability After Discomplete Spinal Cord Injury: A Case Report |
title_full_unstemmed | Supraspinal and Afferent Signaling Facilitate Spinal Sensorimotor Network Excitability After Discomplete Spinal Cord Injury: A Case Report |
title_short | Supraspinal and Afferent Signaling Facilitate Spinal Sensorimotor Network Excitability After Discomplete Spinal Cord Injury: A Case Report |
title_sort | supraspinal and afferent signaling facilitate spinal sensorimotor network excitability after discomplete spinal cord injury: a case report |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323764/ https://www.ncbi.nlm.nih.gov/pubmed/32655351 http://dx.doi.org/10.3389/fnins.2020.00552 |
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